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    Zfp677 zinc finger protein 677 [ Mus musculus (house mouse) ]

    Gene ID: 210503, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp677provided by MGI
    Official Full Name
    zinc finger protein 677provided by MGI
    Primary source
    MGI:MGI:3053207
    See related
    Ensembl:ENSMUSG00000062743 AllianceGenome:MGI:3053207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tce8; A830058L05Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and nucleolus. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF300 (zinc finger protein 300). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 2.1), CNS E18 (RPKM 1.2) and 20 other tissues See more
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    Genomic context

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    Location:
    17 A3.2; 17 11.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21603972..21619527)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21383707..21399265)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 150 Neighboring gene STARR-positive B cell enhancer ABC_E7494 Neighboring gene zinc finger protein 677 pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene zinc finger protein 54 Neighboring gene STARR-seq mESC enhancer starr_42007 Neighboring gene STARR-positive B cell enhancer ABC_E9941 Neighboring gene STARR-positive B cell enhancer ABC_E8655 Neighboring gene zinc finger protein 51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KRAB-zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172486.2 → NP_766074.2  KRAB-zinc finger protein

      See identical proteins and their annotated locations for NP_766074.2

      Status: VALIDATED

      Source sequence(s)
      AI505073, AK043955, BB641850
      Consensus CDS
      CCDS28439.1
      UniProtKB/TrEMBL
      Q6PEP4
      Related
      ENSMUSP00000052667.5, ENSMUST00000056107.11
      Conserved Domains (3) summary
      COG5048
      Location:183 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      21603972..21619527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249620.2 → XP_030105480.1  KRAB-zinc finger protein isoform X2

      UniProtKB/TrEMBL
      Q6PEP4
      Conserved Domains (3) summary
      COG5048
      Location:183 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    2. XM_030249619.2 → XP_030105479.1  KRAB-zinc finger protein isoform X1

      UniProtKB/TrEMBL
      Q6PEP4
      Related
      ENSMUSP00000125295.2, ENSMUST00000162659.2
      Conserved Domains (3) summary
      COG5048
      Location:183 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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