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    Syt3 synaptotagmin III [ Mus musculus (house mouse) ]

    Gene ID: 20981, updated on 8-May-2024

    Summary

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    Official Symbol
    Syt3provided by MGI
    Official Full Name
    synaptotagmin IIIprovided by MGI
    Primary source
    MGI:MGI:99665
    See related
    Ensembl:ENSMUSG00000030731 AllianceGenome:MGI:99665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sytIII
    Summary
    Enables calcium-dependent phospholipid binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of dendrite extension; regulation of dopamine secretion; and regulation of vesicle-mediated transport. Predicted to act upstream of or within cell differentiation and exocytosis. Predicted to be located in endosome. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human SYT3 (synaptotagmin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 17.0), cortex adult (RPKM 9.0) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 28.83 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44032197..44049454)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44382773..44400030)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene STARR-seq mESC enhancer starr_18792 Neighboring gene predicted gene, 39001 Neighboring gene STARR-positive B cell enhancer ABC_E4924 Neighboring gene STARR-seq mESC enhancer starr_18797 Neighboring gene predicted gene, 39002 Neighboring gene leucine rich repeat containing 4B Neighboring gene predicted gene, 39003

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fast resupply of synaptic vesicles requires synaptotagmin-3. Weingarten DJ, et al. Nature, 2022 Nov. PMID 36261524
    2. Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain. Fukuda M, et al. J Biol Chem, 1995 Nov 3. PMID 7592870
    3. Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke. Lu H, et al. Cell Rep, 2023 Mar 28. PMID 36892998
    4. Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration. Masztalerz A, et al. J Cell Sci, 2007 Jan 15. PMID 17179206
    5. Genomic structures of synaptotagmin II protein: comparison of exon-intron organization of the synaptotagmin gene family. Fukuda M, et al. Biochem Biophys Res Commun, 2000 Apr 13. PMID 10753658

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
      Title: Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
    2. Fast resupply of synaptic vesicles requires synaptotagmin-3.
      Title: Fast resupply of synaptic vesicles requires synaptotagmin-3.
    3. the combined inactivation of all 3 E-Syt genes has no effect on mouse viability or fertility.
      Title: Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114116.2 → NP_001107588.1  synaptotagmin-3

      See identical proteins and their annotated locations for NP_001107588.1

      Status: VALIDATED

      Source sequence(s)
      AC152939
      Consensus CDS
      CCDS21205.1
      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Related
      ENSMUSP00000114070.2, ENSMUST00000118962.8
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    2. NM_001417323.1 → NP_001404252.1  synaptotagmin-3

      Status: VALIDATED

      Source sequence(s)
      AC152939
      UniProtKB/TrEMBL
      G3X9Y1

    3. NM_001417324.1 → NP_001404253.1  synaptotagmin-3

      Status: VALIDATED

      Source sequence(s)
      AC152939
      UniProtKB/TrEMBL
      G3X9Y1

    4. NM_001417325.1 → NP_001404254.1  synaptotagmin-3

      Status: VALIDATED

      Source sequence(s)
      AC152939
      UniProtKB/TrEMBL
      G3X9Y1
      Related
      ENSMUSP00000112968.2, ENSMUST00000120262.2

    5. NM_001417326.1 → NP_001404255.1  synaptotagmin-3

      Status: VALIDATED

      Source sequence(s)
      AC152939
      UniProtKB/TrEMBL
      G3X9Y1

    6. NM_016663.4 → NP_057872.3  synaptotagmin-3

      See identical proteins and their annotated locations for NP_057872.3

      Status: VALIDATED

      Source sequence(s)
      AC152939
      Consensus CDS
      CCDS21205.1
      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Related
      ENSMUSP00000112432.2, ENSMUST00000118831.8
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44032197..44049454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242318.1 → XP_030098178.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    2. XM_036152863.1 → XP_036008756.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    3. XM_017322088.1 → XP_017177577.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    4. XM_017322089.1 → XP_017177578.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    5. XM_030242319.1 → XP_030098179.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    6. XM_036152864.1 → XP_036008757.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    7. XM_017322087.2 → XP_017177576.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    8. XM_030242317.2 → XP_030098177.1  synaptotagmin-3 isoform X1

      UniProtKB/Swiss-Prot
      O35681, P97791, Q80WV1
      UniProtKB/TrEMBL
      G3X9Y1
      Conserved Domains (2) summary
      cd08385
      Location:297 → 421
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:430 → 564
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35681.2 GenPept UniProtKB/Swiss-Prot:O35681

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