Tbc1d25 TBC1 domain family, member 25 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbc1d25provided by MGI
Official Full Name: TBC1 domain family, member 25provided by MGI
Primary source: MGI:MGI:2444862
See related: Ensembl:ENSMUSG00000039201 AllianceGenome:MGI:2444862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oatl1; DXHXS7927e; 6330576A08Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of autophagosome maturation. Predicted to act upstream of or within autophagy. Predicted to be located in cytoplasmic vesicle. Predicted to be active in autophagosome. Orthologous to human TBC1D25 (TBC1 domain family member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 10.2), whole brain E14.5 (RPKM 8.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.69 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (8020709..8042420, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (8154470..8176181, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TBC1D25 alleviates nonalcoholic steatohepatitis by inhibiting abnormal lipid accumulation and inflammation.
Title: TBC1D25 alleviates nonalcoholic steatohepatitis by inhibiting abnormal lipid accumulation and inflammation.
TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway.
Title: TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway.
OATL1 has a role in autophagy.
Title: OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagosome maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TBC1 domain family member 25

Names: ornithine aminotransferase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166437.1 → NP_001159909.1 TBC1 domain family member 25 isoform 2

Status: VALIDATED

Source sequence(s)

AK078145, AK207073, BC128565

Consensus CDS

CCDS52989.1

UniProtKB/TrEMBL

A2VCT6, E9PWX7

Related

ENSMUSP00000131652.2, ENSMUST00000172020.8

Conserved Domains (1) summary

smart00164
Location:260 → 489

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
NM_172478.4 → NP_766066.3 TBC1 domain family member 25 isoform 1

Status: VALIDATED

Source sequence(s)

AL663032

Consensus CDS

CCDS29988.1

UniProtKB/TrEMBL

A0A6I8MX15, A2BD48

Related

ENSMUSP00000159357.2, ENSMUST00000239441.2

Conserved Domains (1) summary

smart00164
Location:225 → 454

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

8020709..8042420 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251294.1 → XP_030107154.1 TBC1 domain family member 25 isoform X1

UniProtKB/TrEMBL

S4R2S6

Related

ENSMUSP00000138768.2, ENSMUST00000143984.2

Conserved Domains (1) summary

smart00164
Location:97 → 326

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs