Syngr3 synaptogyrin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syngr3provided by MGI
Official Full Name: synaptogyrin 3provided by MGI
Primary source: MGI:MGI:1341881
See related: Ensembl:ENSMUSG00000007021 AllianceGenome:MGI:1341881
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables SH2 domain binding activity and protein N-terminus binding activity. Involved in positive regulation of transporter activity and regulated exocytosis. Located in neuromuscular junction. Is active in synaptic vesicle. Is expressed in several structures, including central nervous system; eye; and peripheral nervous system ganglion. Orthologous to human SYNGR3 (synaptogyrin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 49.6), frontal lobe adult (RPKM 44.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.47 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24904066..24908923, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24685092..24689949, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice.
Title: The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice.
In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2[R1441G] mutant mouse model of Parkinson's disease.
Title: In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2(R1441G) mutant mouse model of Parkinson's disease.
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Title: Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
This work identified Synaptogyrin-3 as the binding partner of Tau on synaptic vesicles, revealing a new presynapse-specific Tau interactor.
Title: Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.
A novel interaction between dopamine transporter (DAT) and synaptogyrin-3 suggests a physical and functional link between DAT and the vesicular dopamine system.
Title: Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3.
Subcellular fractionation and immunoprecipitation of synaptic vesicles from mouse brain show that synaptogyrin 3 is associated with synaptic vesicles and can reside on the same synaptic vesicle with synaptogyrin 1.
Title: Characterization of synaptogyrin 3 as a new synaptic vesicle protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH2 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle priming	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IEP Inferred from Expression Pattern more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: synaptogyrin-3

Names: Sgyr III; synaptogryin III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.