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    Ttc28 tetratricopeptide repeat domain 28 [ Mus musculus (house mouse) ]

    Gene ID: 209683, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ttc28provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 28provided by MGI
    Primary source
    MGI:MGI:2140873
    See related
    Ensembl:ENSMUSG00000033209 AllianceGenome:MGI:2140873
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TPRBK; 6030435N04; 2310015L07Rik
    Summary
    Predicted to enable kinase binding activity. Predicted to act upstream of or within regulation of mitotic cell cycle. Predicted to be located in microtubule cytoskeleton and midbody. Is expressed in several structures, including central nervous system; heart; and retina. Orthologous to human TTC28 (tetratricopeptide repeat domain 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 8.8), CNS E14 (RPKM 8.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttc28 in Genome Data Viewer
    Location:
    5 F; 5 53.74 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (111027652..111437646)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110879785..111289780)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ES cell cis-regulatory motif 10b Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:111268841-111269029 Neighboring gene STARR-seq mESC enhancer starr_13970 Neighboring gene HscB iron-sulfur cluster co-chaperone Neighboring gene checkpoint kinase 2 Neighboring gene STARR-seq mESC enhancer starr_13974 Neighboring gene microRNA 701 Neighboring gene STARR-seq mESC enhancer starr_13978 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:111589073-111589226 Neighboring gene STARR-positive B cell enhancer mm9_chr5:111607344-111607645 Neighboring gene predicted gene, 35628 Neighboring gene phosphatidylinositol transfer protein, beta Neighboring gene predicted gene, 36027 Neighboring gene meningioma 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Izumiyama T, et al. Gene, 2012 Dec 15. PMID 23036704
    2. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7623

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 28
    Names
    TPR repeat protein 28
    NP_001254551.1
    XP_006534908.1
    XP_006534909.1
    XP_030110193.1
    XP_030110194.1
    XP_030110195.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267622.1 → NP_001254551.1  tetratricopeptide repeat protein 28

      See identical proteins and their annotated locations for NP_001254551.1

      Status: INFERRED

      Source sequence(s)
      AC121934, AC122226, AC124425, AC155173, AW492543, BC046779
      Consensus CDS
      CCDS59682.1
      UniProtKB/Swiss-Prot
      J3QM46, J3QQ36, Q6P9J6, Q80TL5, Q80XJ3, Q8BV10, Q8C0F2
      UniProtKB/TrEMBL
      A0A0A0MQN9
      Related
      ENSMUSP00000137609.2, ENSMUST00000156290.9
      Conserved Domains (7) summary
      smart00028
      Location:388 → 420
      TPR; Tetratricopeptide repeats
      COG0457
      Location:688 → 989
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:85 → 115
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:1384 → 1707
      CHAT; CHAT domain
      pfam13176
      Location:953 → 988
      TPR_7; Tetratricopeptide repeat
      pfam13414
      Location:88 → 151
      TPR_11; TPR repeat
      pfam13424
      Location:309 → 380
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      111027652..111437646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534845.5 → XP_006534908.1  tetratricopeptide repeat protein 28 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQN9
      Conserved Domains (5) summary
      PHA03377
      Location:1950 → 2334
      PHA03377; EBNA-3C; Provisional
      TIGR02917
      Location:27 → 838
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:495 → 523
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:1291 → 1614
      CHAT; CHAT domain
      pfam17874
      Location:733 → 1053
      TPR_MalT; MalT-like TPR region

    2. XM_030254333.2 → XP_030110193.1  tetratricopeptide repeat protein 28 isoform X3

      Conserved Domains (5) summary
      PHA03377
      Location:1884 → 2268
      PHA03377; EBNA-3C; Provisional
      COG0457
      Location:278 → 552
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:429 → 457
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:834 → 904
      TPR_12; Tetratricopeptide repeat
      pfam12770
      Location:1225 → 1548
      CHAT; CHAT domain

    3. XM_030254334.2 → XP_030110194.1  tetratricopeptide repeat protein 28 isoform X3

      Conserved Domains (5) summary
      PHA03377
      Location:1884 → 2268
      PHA03377; EBNA-3C; Provisional
      COG0457
      Location:278 → 552
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:429 → 457
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:834 → 904
      TPR_12; Tetratricopeptide repeat
      pfam12770
      Location:1225 → 1548
      CHAT; CHAT domain

    4. XM_030254335.2 → XP_030110195.1  tetratricopeptide repeat protein 28 isoform X3

      Conserved Domains (5) summary
      PHA03377
      Location:1884 → 2268
      PHA03377; EBNA-3C; Provisional
      COG0457
      Location:278 → 552
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:429 → 457
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:834 → 904
      TPR_12; Tetratricopeptide repeat
      pfam12770
      Location:1225 → 1548
      CHAT; CHAT domain

    5. XM_006534846.5 → XP_006534909.1  tetratricopeptide repeat protein 28 isoform X2

      UniProtKB/TrEMBL
      A0A0A0MQN9
      Conserved Domains (5) summary
      PHA03377
      Location:1931 → 2315
      PHA03377; EBNA-3C; Provisional
      TIGR02917
      Location:9 → 819
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:476 → 504
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:1272 → 1595
      CHAT; CHAT domain
      pfam17874
      Location:714 → 1034
      TPR_MalT; MalT-like TPR region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024477.3: Suppressed sequence

      Description
      NM_024477.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XJ3.3 GenPept UniProtKB/Swiss-Prot:Q80XJ3

    Gene LinkOut

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