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    Eif2b1 eukaryotic translation initiation factor 2B, subunit alpha [ Mus musculus (house mouse) ]

    Gene ID: 209354, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Eif2b1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit alphaprovided by MGI
    Primary source
    MGI:MGI:2384802
    See related
    Ensembl:ENSMUSG00000029388 AllianceGenome:MGI:2384802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EIF2BA; D5Ertd406e
    Summary
    This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits. The eIF2B complex is a critical regulator of protein synthesis acting as the guanine nucleotide exchange factor for eIF2 to enable the formation of ternary complex that is required for the initiation of mRNA translation. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in placenta adult (RPKM 18.0), liver E14 (RPKM 13.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif2b1 in Genome Data Viewer
    Location:
    5 F; 5 63.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124708277..124717194, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124570214..124579131, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3619 Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene DEAD box helicase 55 Neighboring gene STARR-positive B cell enhancer ABC_E8083 Neighboring gene general transcription factor IIH, polypeptide 3 Neighboring gene STARR-positive B cell enhancer ABC_E10353 Neighboring gene tectonic family member 2 Neighboring gene STARR-seq mESC enhancer starr_14344

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new function and complexity for protein translation initiation factor eIF2B. Jennings MD, et al. Cell Cycle, 2014. PMID 25486352, Free PMC Article
    2. Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation. Wortham NC, et al. FASEB J, 2014 May. PMID 24532666
    3. Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Pavitt GD, et al. Biochem Soc Trans, 2009 Dec. PMID 19909266
    4. Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions. Kubica N, et al. Prog Nucleic Acid Res Mol Biol, 2006. PMID 16891174
    5. Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease. Cabilly Y, et al. PLoS One, 2012. PMID 23056417, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These are the first data that mechanistically link eIF2Bepsilon abundance to skeletal myofibre hypertrophy.
      Title: Eukaryotic initiation factor 2B epsilon induces cap-dependent translation and skeletal muscle hypertrophy.
    2. A point mutation in translation initiation factor eIF2B leads to Vanishing White Matter disease.
      Title: A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
    3. Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha phosphorylation, reduction of eIF2B activity, and inhibition of eIF4F complex formation.
      Title: Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6458

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit alpha
    Names
    eIF-2B GDP-GTP exchange factor subunit alpha
    eIF2B GDP-GTP exchange factor subunit alpha
    eukaryotic translation initiation factor 2B, subunit 1 (alpha)
    eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa)
    translation initiation factor eIF-2B subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145371.4 → NP_663346.1  translation initiation factor eIF2B subunit alpha

      See identical proteins and their annotated locations for NP_663346.1

      Status: REVIEWED

      Source sequence(s)
      AK133695, DV649595
      Consensus CDS
      CCDS39282.1
      UniProtKB/Swiss-Prot
      Q99LC8
      UniProtKB/TrEMBL
      Q3UZR8
      Related
      ENSMUSP00000031334.9, ENSMUST00000031334.15
      Conserved Domains (2) summary
      COG1184
      Location:5 → 305
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:17 → 293
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124708277..124717194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530275.5 → XP_006530338.1  translation initiation factor eIF2B subunit alpha isoform X1

      Conserved Domains (1) summary
      pfam01008
      Location:17 → 185
      IF-2B; Initiation factor 2 subunit family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LC8.1 GenPept UniProtKB/Swiss-Prot:Q99LC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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