Ido2 indoleamine 2,3-dioxygenase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ido2provided by MGI
Official Full Name: indoleamine 2,3-dioxygenase 2provided by MGI
Primary source: MGI:MGI:2142489
See related: Ensembl:ENSMUSG00000031549 AllianceGenome:MGI:2142489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ido-2; Indol1; C230043N17Rik
Summary: Enables indoleamine 2,3-dioxygenase activity. Acts upstream of or within tryptophan catabolic process to kynurenine. Located in cytoplasm. Is expressed in corpus striatum. Orthologous to human IDO2 (indoleamine 2,3-dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 13.5), genital fat pad adult (RPKM 2.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 12.58 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (25021908..25066430, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (24531892..24576414, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.
Title: Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.
Absence of indoleamine 2,3dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
Title: Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.
Title: The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.
Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses.
Title: Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses.
Data showed that Ido2 depletion in immune cells effectively reduces lung cancer burden, indicating that Ido2 plays an important role in tumor progression and an important immune regulator in the tumor microenvironment.
Title: Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma.
The current study shows that the Ido1 and Ido2 genes are imprinted and maternally expressed in mouse placentas. DNA methylation analysis demonstrates that nine CpG sites at the Ido1 promoter constitute a differentially methylated region that is highly methylated in sperm but unmethylated in oocytes
Title: Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss.
IDO2-shRNA treatment also decreased the percentage of Tregs and T cell apoptosis in draining lymph nodes
Title: [Knockdown of indoleamine 2, 3-dioxygenase 2 (IDO2)gene inhibits tumor growth and enhances immune function in mice bearing melanoma].
IDO is a critical regulator of acute pulmonary inflammation.
Title: Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway.
Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.
Title: Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.
Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism.
Title: Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (8) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables indoleamine 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables indoleamine 2,3-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables indoleamine 2,3-dioxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables indoleamine 2,3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to kynurenine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tryptophan catabolic process to kynurenine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tryptophan catabolic process to kynurenine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tryptophan catabolic process to kynurenine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: indoleamine 2,3-dioxygenase 2

Names: indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1

NP_666061.3

EC 1.13.11.52

XP_006509109.1

EC 1.13.11.52

XP_006509110.1

EC 1.13.11.52

XP_006509111.1

EC 1.13.11.52

XP_011240433.1

EC 1.13.11.52

XP_030099238.1

EC 1.13.11.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145949.2 → NP_666061.3 indoleamine 2,3-dioxygenase 2

See identical proteins and their annotated locations for NP_666061.3

Status: VALIDATED

Source sequence(s)

AC114602, BX637885, EF137182

Consensus CDS

CCDS40298.2

UniProtKB/Swiss-Prot

A4UHF3, E9QKA9, Q8R0V5

Related

ENSMUSP00000113979.2, ENSMUST00000121992.2

Conserved Domains (1) summary

pfam01231
Location:15 → 399

IDO; Indoleamine 2,3-dioxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

25021908..25066430 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509046.5 → XP_006509109.1 indoleamine 2,3-dioxygenase 2 isoform X1

Conserved Domains (1) summary

pfam01231
Location:38 → 367

IDO; Indoleamine 2,3-dioxygenase
XM_006509047.4 → XP_006509110.1 indoleamine 2,3-dioxygenase 2 isoform X2

See identical proteins and their annotated locations for XP_006509110.1

Conserved Domains (1) summary

pfam01231
Location:1 → 334

IDO; Indoleamine 2,3-dioxygenase
XM_006509048.2 → XP_006509111.1 indoleamine 2,3-dioxygenase 2 isoform X2

See identical proteins and their annotated locations for XP_006509111.1

Related

ENSMUST00000140417.9

Conserved Domains (1) summary

pfam01231
Location:1 → 334

IDO; Indoleamine 2,3-dioxygenase
XM_030243378.1 → XP_030099238.1 indoleamine 2,3-dioxygenase 2 isoform X3

Conserved Domains (1) summary

cl21721
Location:18 → 240

IDO; Indoleamine 2,3-dioxygenase
XM_011242131.4 → XP_011240433.1 indoleamine 2,3-dioxygenase 2 isoform X4

Conserved Domains (1) summary

cl21721
Location:18 → 240

IDO; Indoleamine 2,3-dioxygenase