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    Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 20917, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Suclg2provided by MGI
    Official Full Name
    succinate-Coenzyme A ligase, GDP-forming, beta subunitprovided by MGI
    Primary source
    MGI:MGI:1306824
    See related
    Ensembl:ENSMUSG00000061838 AllianceGenome:MGI:1306824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G-SCS; GTPSCS; D6Wsu120e; SCS-betaG
    Summary
    Predicted to enable succinate-CoA ligase (GDP-forming) activity and succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 29.5), liver adult (RPKM 17.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 D2; 6 44.63 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (95449992..95695799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (95473009..95718858, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16742 Neighboring gene cDNA sequence AY512915 Neighboring gene STARR-seq mESC enhancer starr_16743 Neighboring gene STARR-seq mESC enhancer starr_16744 Neighboring gene predicted gene, 53325 Neighboring gene STARR-seq mESC enhancer starr_16745 Neighboring gene STARR-seq mESC enhancer starr_16746 Neighboring gene STARR-seq mESC enhancer starr_16747 Neighboring gene STARR-positive B cell enhancer ABC_E10396 Neighboring gene STARR-seq mESC enhancer starr_16748 Neighboring gene STARR-seq mESC enhancer starr_16749 Neighboring gene STARR-positive B cell enhancer ABC_E4846 Neighboring gene STARR-positive B cell enhancer ABC_E11325 Neighboring gene STARR-positive B cell enhancer ABC_E4847 Neighboring gene STARR-seq mESC enhancer starr_16750 Neighboring gene predicted gene, 32009 Neighboring gene STARR-seq mESC enhancer starr_16751 Neighboring gene STARR-seq mESC enhancer starr_16752 Neighboring gene predicted gene, 38864

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Kacso G, et al. Biochem J, 2016 Oct 15. PMID 27496549, Free PMC Article
    2. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Ramirez A, et al. Hum Mol Genet, 2014 Dec 15. PMID 25027320, Free PMC Article
    3. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. Johnson JD, et al. J Biol Chem, 1998 Oct 16. PMID 9765291
    4. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Nguyen TD, et al. Blood, 2019 Jan 10. PMID 30498063
    5. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, et al. Cell Stem Cell, 2019 Apr 4. PMID 30951662

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91183

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NAD+) activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in succinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of succinate-CoA ligase complex (GDP-forming) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of succinate-CoA ligase complex (GDP-forming) ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
    Names
    GTP-specific succinyl-CoA synthetase beta subunit
    succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
    succinyl-CoA synthetase beta-G chain
    NP_001313487.1
    NP_001397340.1
    NP_035637.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326558.2 → NP_001313487.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC121612, AC125225, AC135018
      Consensus CDS
      CCDS85100.1
      UniProtKB/TrEMBL
      C6EQH3
      Related
      ENSMUSP00000078774.7, ENSMUST00000079847.8
      Conserved Domains (3) summary
      PRK00696
      Location:2 → 372
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:258 → 372
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:1 → 199
      ATP-grasp_2; ATP-grasp domain

    2. NM_001410411.1 → NP_001397340.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121612, AC125225, AC135018

    3. NM_011507.4 → NP_035637.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_035637.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC121612, AC125225, AC135018
      Consensus CDS
      CCDS20381.1
      UniProtKB/Swiss-Prot
      Q3T9B8, Q3TJQ5, Q3TK63, Q66JT3, Q7TMY3, Q80VV1, Q8K2K9, Q9Z2I8
      UniProtKB/TrEMBL
      C6EQH3
      Related
      ENSMUSP00000144827.2, ENSMUST00000204224.3
      Conserved Domains (3) summary
      PRK00696
      Location:40 → 421
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:307 → 421
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:40 → 248
      ATP-grasp_2; ATP-grasp domain

    RNA

    1. NR_177067.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121612, AC125225, AC135018

    2. NR_177068.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121612, AC125225, AC135018

    3. NR_177069.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121612, AC125225, AC135018

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      95449992..95695799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2I8.3 GenPept UniProtKB/Swiss-Prot:Q9Z2I8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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