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    Stra8 stimulated by retinoic acid gene 8 [ Mus musculus (house mouse) ]

    Gene ID: 20899, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Stra8provided by MGI
    Official Full Name
    stimulated by retinoic acid gene 8provided by MGI
    Primary source
    MGI:MGI:107917
    See related
    Ensembl:ENSMUSG00000029848 AllianceGenome:MGI:107917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in several processes, including activation of meiosis; cellular response to retinoic acid; and germ cell development. Located in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; gonad; spleen primordium; and trophoblast giant cell. Orthologous to human STRA8 (stimulated by retinoic acid 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 2.9) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B1; 6 15.2 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34897098..34916279)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34920163..34939344)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 140 Neighboring gene cell cycle regulator of NHEJ Neighboring gene WD repeat domain 91 Neighboring gene STARR-positive B cell enhancer mm9_chr6:34860831-34861132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34902551-34902660 Neighboring gene solute carrier family 23 member 4 Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene STARR-seq mESC enhancer starr_15552 Neighboring gene STARR-positive B cell enhancer ABC_E2779 Neighboring gene predicted gene, 33046

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells. Ishihara T, et al. Reproduction, 2023 May 1. PMID 36866926
    2. STRA8 induces transcriptional changes in germ cells during spermatogonial development. Gewiss RL, et al. Mol Reprod Dev, 2021 Feb. PMID 33400349, Free PMC Article
    3. Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway. Shen X, et al. Int J Mol Med, 2018 Nov. PMID 30106128
    4. Stimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesis. Ma HT, et al. Asian J Androl, 2018 Sep-Oct. PMID 29848833, Free PMC Article
    5. Retinoic acid induces multiple hallmarks of the prospermatogonia-to-spermatogonia transition in the neonatal mouse. Busada JT, et al. Biol Reprod, 2014 Mar. PMID 24478393, Free PMC Article

    See all (185) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells.
      Title: STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells.
    2. Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells.
      Title: Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells.
    3. Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
      Title: Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
    4. The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis.
      Title: The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis.
    5. Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mousedagger.
      Title: Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse†.
    6. STRA8 induces transcriptional changes in germ cells during spermatogonial development.
      Title: STRA8 induces transcriptional changes in germ cells during spermatogonial development.
    7. Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse.
      Title: Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse.
    8. Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis.
      Title: Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis.
    9. Here, the authors examined cells undergoing meiotic initiation in mice, and found that initiation involves the dramatic upregulation of a transcriptional network of thousands of genes whose expression is not limited to meiosis. This broad gene expression program is directly upregulated by STRA8, encoded by a germ cell-specific gene required for meiotic initiation.
      Title: Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice.
    10. Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
      Title: Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stimulated by retinoic acid gene 8 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410379.1 → NP_001397308.1  stimulated by retinoic acid gene 8 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153869

    2. NM_001410380.1 → NP_001397309.1  stimulated by retinoic acid gene 8 protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153869
      UniProtKB/TrEMBL
      F2Z435
      Related
      ENSMUSP00000110649.2, ENSMUST00000114997.3

    3. NM_009292.3 → NP_033318.1  stimulated by retinoic acid gene 8 protein isoform 1

      See identical proteins and their annotated locations for NP_033318.1

      Status: VALIDATED

      Source sequence(s)
      AC153869
      Consensus CDS
      CCDS39458.1
      UniProtKB/Swiss-Prot
      P70278, Q496Q5
      Related
      ENSMUSP00000110651.2, ENSMUST00000114999.8
      Conserved Domains (1) summary
      cl00081
      Location:30 → 90
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34897098..34916279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241270.1 → XP_011239572.1  stimulated by retinoic acid gene 8 protein isoform X1

      See identical proteins and their annotated locations for XP_011239572.1

      UniProtKB/Swiss-Prot
      P70278, Q496Q5
      Related
      ENSMUSP00000031876.5, ENSMUST00000031876.12
      Conserved Domains (1) summary
      cl00081
      Location:30 → 90
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70278.1 GenPept UniProtKB/Swiss-Prot:P70278

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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