Npb neuropeptide B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npbprovided by MGI
Official Full Name: neuropeptide Bprovided by MGI
Primary source: MGI:MGI:2387153
See related: Ensembl:ENSMUSG00000044034 AllianceGenome:MGI:2387153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PPL7; mPPL7
Summary: Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and feeding behavior. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in extracellular space. Orthologous to human NPB (neuropeptide B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 41.4), ovary adult (RPKM 39.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.33 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120499303..120499926)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120608477..120609100)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role for GPR7 and its endogenous ligands, neuropeptide B and neuropeptide W, in regulating energy homeostasis.
Title: Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.
identified a neuropeptide modified with bromine; an endogenous ligand for GPR7
Title: Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.
NPB is a factor in the modulation of responses to inflammatory pain and body weight homeostasis.
Title: Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: neuropeptide B

Names: preproneuropeptide B; preproprotein L7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.