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    Zfp280c zinc finger protein 280C [ Mus musculus (house mouse) ]

    Gene ID: 208968, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp280cprovided by MGI
    Official Full Name
    zinc finger protein 280Cprovided by MGI
    Primary source
    MGI:MGI:2387585
    See related
    Ensembl:ENSMUSG00000036916 AllianceGenome:MGI:2387585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Suhw3; Zfp633; Znf280c; mKIAA1584
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in brain; dorsal root ganglion; early conceptus; and spinal cord. Orthologous to human ZNF280C (zinc finger protein 280C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 8.8), CNS E14 (RPKM 8.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A5; X 25.68 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47630503..47683599, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48541626..48594648, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene solute carrier family 25 (mitochondrial carrier, brain), member 14 Neighboring gene G-protein coupled receptor 119

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38010

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 280C
    Names
    suppressor of hairy wing homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166648.2 → NP_001160120.1  zinc finger protein 280C isoform 1

      See identical proteins and their annotated locations for NP_001160120.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI481209, AK141491, AL669901
      Consensus CDS
      CCDS30111.1
      UniProtKB/Swiss-Prot
      B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
      Related
      ENSMUSP00000086288.5, ENSMUST00000088898.11
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    2. NM_001166649.2 → NP_001160121.1  zinc finger protein 280C isoform 2

      See identical proteins and their annotated locations for NP_001160121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different segment for its 5' UTR and uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AI481209, AL669901
      Consensus CDS
      CCDS53064.1
      UniProtKB/Swiss-Prot
      Q6P3Y5
      Related
      ENSMUSP00000072138.6, ENSMUST00000072292.12
      Conserved Domains (2) summary
      sd00017
      Location:353 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:47 → 218
      DUF4195; Domain of unknown function (DUF4195)

    3. NM_001166650.2 → NP_001160122.1  zinc finger protein 280C isoform 3

      See identical proteins and their annotated locations for NP_001160122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks part of the 5' UTR and an alternate exon in the 3' coding region which shifts the reading frame, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AI481209, AK141491, AL669901
      Consensus CDS
      CCDS53065.1
      UniProtKB/Swiss-Prot
      Q6P3Y5
      Related
      ENSMUSP00000110590.3, ENSMUST00000114940.9
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    4. NM_001358792.1 → NP_001345721.1  zinc finger protein 280C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AI481209, AL669901
      Conserved Domains (2) summary
      sd00017
      Location:339 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:33 → 208
      DUF4195; Domain of unknown function (DUF4195)

    5. NM_153532.4 → NP_705760.2  zinc finger protein 280C isoform 1

      See identical proteins and their annotated locations for NP_705760.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI481209, AK141491, AL669901
      Consensus CDS
      CCDS30111.1
      UniProtKB/Swiss-Prot
      B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
      Related
      ENSMUSP00000075933.7, ENSMUST00000076635.13
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      47630503..47683599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161884.1 → XP_036017777.1  zinc finger protein 280C isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:339 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:33 → 208
      DUF4195; Domain of unknown function (DUF4195)

    2. XM_036161882.1 → XP_036017775.1  zinc finger protein 280C isoform X1

      UniProtKB/Swiss-Prot
      B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    3. XM_036161885.1 → XP_036017778.1  zinc finger protein 280C isoform X4

      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    4. XM_036161881.1 → XP_036017774.1  zinc finger protein 280C isoform X1

      UniProtKB/Swiss-Prot
      B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    5. XM_006541464.5 → XP_006541527.1  zinc finger protein 280C isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:339 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:33 → 208
      DUF4195; Domain of unknown function (DUF4195)

    6. XM_006541458.5 → XP_006541521.1  zinc finger protein 280C isoform X1

      See identical proteins and their annotated locations for XP_006541521.1

      UniProtKB/Swiss-Prot
      B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    7. XM_036161883.1 → XP_036017776.1  zinc finger protein 280C isoform X1

      UniProtKB/Swiss-Prot
      B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    8. XM_030251282.2 → XP_030107142.1  zinc finger protein 280C isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:339 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:33 → 208
      DUF4195; Domain of unknown function (DUF4195)

    9. XM_030251281.2 → XP_030107141.1  zinc finger protein 280C isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:353 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:47 → 218
      DUF4195; Domain of unknown function (DUF4195)

    10. XM_030251283.2 → XP_030107143.1  zinc finger protein 280C isoform X4

      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    11. XM_006541459.5 → XP_006541522.1  zinc finger protein 280C isoform X1

      See identical proteins and their annotated locations for XP_006541522.1

      UniProtKB/Swiss-Prot
      B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
      Conserved Domains (2) summary
      sd00017
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:56 → 231
      DUF4195; Domain of unknown function (DUF4195)

    12. XM_036161887.1 → XP_036017780.1  zinc finger protein 280C isoform X5

      Conserved Domains (2) summary
      sd00017
      Location:353 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:47 → 222
      DUF4195; Domain of unknown function (DUF4195)

    13. XM_030251284.2 → XP_030107144.1  zinc finger protein 280C isoform X5

      Conserved Domains (2) summary
      sd00017
      Location:353 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:47 → 222
      DUF4195; Domain of unknown function (DUF4195)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3Y5.1 GenPept UniProtKB/Swiss-Prot:Q6P3Y5

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