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    Thnsl1 threonine synthase-like 1 (bacterial) [ Mus musculus (house mouse) ]

    Gene ID: 208967, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Thnsl1provided by MGI
    Official Full Name
    threonine synthase-like 1 (bacterial)provided by MGI
    Primary source
    MGI:MGI:2139347
    See related
    Ensembl:ENSMUSG00000048550 AllianceGenome:MGI:2139347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human THNSL1 (threonine synthase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 5.4), CNS E18 (RPKM 4.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A3; 2 14.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (21210236..21232948)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (21205425..21228134)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphoribosyltransferase domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03890 Neighboring gene STARR-seq mESC enhancer starr_03891 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1240 Neighboring gene STARR-seq mESC enhancer starr_03892 Neighboring gene PHD finger protein 3 pseudogene Neighboring gene predicted gene, 54105

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    threonine synthase-like 1
    Names
    TSH1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001297.2 → NP_001001297.1  threonine synthase-like 1 isoform b

      See identical proteins and their annotated locations for NP_001001297.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AK029518, AK033465, AK083895
      Consensus CDS
      CCDS15721.1
      UniProtKB/TrEMBL
      A2AUG7
      Related
      ENSMUSP00000100017.2, ENSMUST00000102952.8
      Conserved Domains (1) summary
      cl00342
      Location:1 → 212
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

    2. NM_001362772.1 → NP_001349701.1  threonine synthase-like 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AL929117, BB664224
      Consensus CDS
      CCDS15721.1
      UniProtKB/TrEMBL
      A2AUG7
      Related
      ENSMUSP00000100016.2, ENSMUST00000102951.2
      Conserved Domains (1) summary
      cl00342
      Location:1 → 212
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

    3. NM_001362773.1 → NP_001349702.1  threonine synthase-like 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AL929117, BQ551065
      Consensus CDS
      CCDS15721.1
      UniProtKB/TrEMBL
      A2AUG7
      Conserved Domains (1) summary
      cl00342
      Location:1 → 212
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

    4. NM_177588.2 → NP_808256.1  threonine synthase-like 1 isoform a

      See identical proteins and their annotated locations for NP_808256.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK029518, AK083895
      Consensus CDS
      CCDS15720.1
      UniProtKB/Swiss-Prot
      Q8BH55
      UniProtKB/TrEMBL
      Q149D1
      Related
      ENSMUSP00000052452.4, ENSMUST00000054591.10
      Conserved Domains (2) summary
      cd01560
      Location:230 → 733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      pfam01202
      Location:64 → 221
      SKI; Shikimate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      21210236..21232948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497433.4 → XP_006497496.1  threonine synthase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006497496.1

      UniProtKB/Swiss-Prot
      Q8BH55
      UniProtKB/TrEMBL
      Q149D1
      Conserved Domains (2) summary
      cd01560
      Location:230 → 733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      pfam01202
      Location:64 → 221
      SKI; Shikimate kinase

    2. XM_006497431.5 → XP_006497494.1  threonine synthase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006497494.1

      UniProtKB/Swiss-Prot
      Q8BH55
      UniProtKB/TrEMBL
      Q149D1
      Conserved Domains (2) summary
      cd01560
      Location:230 → 733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      pfam01202
      Location:64 → 221
      SKI; Shikimate kinase

    3. XM_006497432.5 → XP_006497495.1  threonine synthase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006497495.1

      UniProtKB/Swiss-Prot
      Q8BH55
      UniProtKB/TrEMBL
      Q149D1
      Conserved Domains (2) summary
      cd01560
      Location:230 → 733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      pfam01202
      Location:64 → 221
      SKI; Shikimate kinase

    4. XM_030249108.2 → XP_030104968.1  threonine synthase-like 1 isoform X2

      UniProtKB/TrEMBL
      A2AUG7
      Conserved Domains (1) summary
      cl00342
      Location:1 → 212
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH55.1 GenPept UniProtKB/Swiss-Prot:Q8BH55

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