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    Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif 18 [ Mus musculus (house mouse) ]

    Gene ID: 208936, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Adamts18provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 18provided by MGI
    Primary source
    MGI:MGI:2442600
    See related
    Ensembl:ENSMUSG00000053399 AllianceGenome:MGI:2442600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADAMTS21; 9630038L21; E130314N14Rik
    Summary
    Predicted to enable metalloendopeptidase activity. Acts upstream of or within negative regulation of platelet aggregation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including alimentary system; brain; eye; lung; and male reproductive gland or organ. Orthologous to human ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E14 (RPKM 1.9), CNS E18 (RPKM 1.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 59.65 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114423755..114575975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (113697123..113849343, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene MON1 homolog B, secretory traffciking associated Neighboring gene synaptonemal complex central element protein 1 like Neighboring gene predicted gene, 30052 Neighboring gene STARR-seq mESC enhancer starr_22763 Neighboring gene predicted gene, 30107 Neighboring gene STARR-seq mESC enhancer starr_22765 Neighboring gene STARR-positive B cell enhancer ABC_E9028 Neighboring gene nudix hydrolase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice. Lin X, et al. Reprod Biol, 2021 Sep. PMID 34388417
    2. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice. Lin X, et al. Reprod Biol, 2021 Sep. PMID 34271244
    3. Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice. Dang S, et al. Biochem Biophys Res Commun, 2018 Feb 19. PMID 29421655
    4. A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice. Zhu R, et al. Am J Pathol, 2018 Feb. PMID 29169989
    5. The development of monoclonal anti-ADAMTS18 antibodies with precise validation of ADAMTS18 post-translational modification status in living organisms. Zhu R, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28843853

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.
      Title: ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.
    2. ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.
      Title: ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.
    3. Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
      Title: Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
    4. ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.
      Title: ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.
    5. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.
      Title: ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.
    6. Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
      Title: Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
    7. Adamts18 links luminal hormone receptor signaling to basement membrane remodeling and stem cell activation.
      Title: The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche.
    8. The underlying molecular mechanisms could be attributed in part to the abnormal vascular remodeling, including deficiency of carotid body (glomus) and aberrant carotid basal lamina. These results indicate a novel function of ADAMTS18 in vascular remodeling and associated thrombus formation.
      Title: Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice.
    9. Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/beta-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in a mouse model.
      Title: Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer.
    10. these data demonstrate a thrombin cleavage site and confirm a short form of ADAMTS-18 presents in vivo.
      Title: Identification of a thrombin cleavage site and a short form of ADAMTS-18.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 18
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403922.1 → NP_001390851.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463

    2. NM_001403923.1 → NP_001390852.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463

    3. NM_001403924.1 → NP_001390853.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463

    4. NM_172466.4 → NP_766054.2  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform a precursor

      See identical proteins and their annotated locations for NP_766054.2

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463
      Consensus CDS
      CCDS40485.1
      UniProtKB/Swiss-Prot
      E9QNK0, Q4VC17, Q8BZD1
      UniProtKB/TrEMBL
      B7ZMV1
      Related
      ENSMUSP00000090801.5, ENSMUST00000093113.5
      Conserved Domains (7) summary
      smart00209
      Location:592 → 644
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:293 → 494
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:749 → 861
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:65 → 203
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1186 → 1216
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:511 → 578
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:935 → 991
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      114423755..114575975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530797.2 → XP_006530860.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X3

      See identical proteins and their annotated locations for XP_006530860.1

      UniProtKB/TrEMBL
      B7ZMV1
      Conserved Domains (6) summary
      smart00209
      Location:512 → 564
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:213 → 414
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:80 → 123
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:669 → 781
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1106 → 1136
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:431 → 498
      ADAM_CR_2; ADAM cysteine-rich domain

    2. XM_006530795.4 → XP_006530858.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1

      UniProtKB/TrEMBL
      B7ZMV1
      Conserved Domains (6) summary
      smart00209
      Location:626 → 678
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:327 → 528
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:99 → 237
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:783 → 895
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1220 → 1250
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:545 → 612
      ADAM_CR_2; ADAM cysteine-rich domain

    3. XM_030243369.1 → XP_030099229.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

      Conserved Domains (5) summary
      smart00209
      Location:180 → 232
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:337 → 449
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:774 → 804
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:99 → 166
      ADAM_CR_2; ADAM cysteine-rich domain
      cl00064
      Location:1 → 82
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    4. XM_030243370.1 → XP_030099230.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

      Conserved Domains (5) summary
      smart00209
      Location:180 → 232
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:337 → 449
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:774 → 804
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:99 → 166
      ADAM_CR_2; ADAM cysteine-rich domain
      cl00064
      Location:1 → 82
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    5. XM_017312629.2 → XP_017168118.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X2

      UniProtKB/TrEMBL
      B7ZMV1
      Conserved Domains (6) summary
      smart00209
      Location:548 → 600
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:249 → 450
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:116 → 159
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:705 → 817
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1142 → 1172
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:467 → 534
      ADAM_CR_2; ADAM cysteine-rich domain

    6. XM_006530801.4 → XP_006530864.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X4

      See identical proteins and their annotated locations for XP_006530864.1

      UniProtKB/TrEMBL
      Q8BKA1
      Conserved Domains (5) summary
      smart00209
      Location:420 → 472
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:121 → 322
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:577 → 689
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1014 → 1044
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:339 → 406
      ADAM_CR_2; ADAM cysteine-rich domain

    7. XM_017312631.2 → XP_017168120.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X6

      Conserved Domains (4) summary
      smart00209
      Location:626 → 678
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:327 → 528
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:99 → 237
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:545 → 612
      ADAM_CR_2; ADAM cysteine-rich domain

    RNA

    1. XR_001778416.2 RNA Sequence

    2. XR_004934786.1 RNA Sequence

    3. XR_878788.3 RNA Sequence

    4. XR_001778415.2 RNA Sequence

    5. XR_004934785.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VC17.2 GenPept UniProtKB/Swiss-Prot:Q4VC17

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