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    Stk10 serine/threonine kinase 10 [ Mus musculus (house mouse) ]

    Gene ID: 20868, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Stk10provided by MGI
    Official Full Name
    serine/threonine kinase 10provided by MGI
    Primary source
    MGI:MGI:1099439
    See related
    Ensembl:ENSMUSG00000020272 AllianceGenome:MGI:1099439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lok; Gek1; mKIAA4026
    Summary
    This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen adult (RPKM 37.1), testis adult (RPKM 17.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stk10 in Genome Data Viewer
    Location:
    11 18.97 cM; 11 A4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32483266..32574595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32533266..32624595)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32442680-32442833 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene STARR-positive B cell enhancer ABC_E5214 Neighboring gene F-box and WD-40 domain protein 11 Neighboring gene STARR-seq mESC enhancer starr_29115 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. Kuramochi S, et al. J Biol Chem, 1997 Sep 5. PMID 9278426
    2. A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870. Edgar AJ, et al. Biosci Rep, 2014 Feb 1. PMID 27919044, Free PMC Article
    3. Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. Kuramochi S, et al. Immunogenetics, 1999 May. PMID 10199912
    4. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. Endo J, et al. FEBS Lett, 2000 Feb 25. PMID 10692593
    5. A novel serine/threonine kinase gene, Gek1, is expressed in meiotic testicular germ cells and primordial germ cells. Yanagisawa M, et al. Mol Reprod Dev, 1996 Dec. PMID 8956278

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
      Title: A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.
    2. These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility.
      Title: LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.
    3. Stk10 is a novel polo-like kinase kinase that cooperates with hSlk to regulate Plk1 function in human cells
      Title: Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4026

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lymphocyte aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lymphocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lymphocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 10
    Names
    germ cell kinase 1
    lymphocyte-oriented kinase
    NP_001346106.1
    NP_001346107.1
    NP_033314.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359177.1 → NP_001346106.1  serine/threonine-protein kinase 10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL669844, BC096624

    2. NM_001359178.1 → NP_001346107.1  serine/threonine-protein kinase 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK148118, AL669844, BC096624, BY207613

    3. NM_009288.2 → NP_033314.2  serine/threonine-protein kinase 10 isoform 1

      See identical proteins and their annotated locations for NP_033314.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA182088, AL669844, BC096624, BC128363, BY207613
      Consensus CDS
      CCDS24529.1
      UniProtKB/Swiss-Prot
      B1ATW8, O55098
      UniProtKB/TrEMBL
      A1A553
      Related
      ENSMUSP00000099885.4, ENSMUST00000102821.4
      Conserved Domains (3) summary
      cd06644
      Location:23 → 314
      STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
      smart00220
      Location:36 → 294
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:754 → 894
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      32483266..32574595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55098.2 GenPept UniProtKB/Swiss-Prot:O55098

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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