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    Diras1 DIRAS family, GTP-binding RAS-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 208666, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Diras1provided by MGI
    Official Full Name
    DIRAS family, GTP-binding RAS-like 1provided by MGI
    Primary source
    MGI:MGI:2183442
    See related
    Ensembl:ENSMUSG00000043670 AllianceGenome:MGI:2183442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RIG; Gbts1; Di-Ras1
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; olfactory epithelium; peripheral nervous system ganglion; and retina. Orthologous to human DIRAS1 (DIRAS family GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 26.6), cortex adult (RPKM 16.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80855423..80862038, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81019589..81025835, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E721 Neighboring gene growth arrest and DNA-damage-inducible 45 beta Neighboring gene STARR-seq mESC enhancer starr_27304 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene STARR-seq mESC enhancer starr_27308 Neighboring gene guanine nucleotide binding protein (G protein), gamma 7 Neighboring gene STARR-seq mESC enhancer starr_27310 Neighboring gene STARR-positive B cell enhancer ABC_E2951 Neighboring gene STARR-positive B cell enhancer ABC_E1807 Neighboring gene STARR-positive B cell enhancer ABC_E10629 Neighboring gene predicted gene 16099 Neighboring gene STARR-positive B cell enhancer ABC_E2952 Neighboring gene solute carrier family 39 (zinc transporter), member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1808 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Fritsch R, et al. Cell, 2013 May 23. PMID 23706742, Free PMC Article
    2. Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis. Reddy HM, et al. BMC Biol, 2021 Sep 9. PMID 34503492, Free PMC Article
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein Di-Ras1
    Names
    distinct subgroup of the Ras family member 1
    small GTP-binding tumor suppressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145217.2 → NP_660252.1  GTP-binding protein Di-Ras1

      See identical proteins and their annotated locations for NP_660252.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057556
      Consensus CDS
      CCDS24040.1
      UniProtKB/Swiss-Prot
      Q91Z61
      Related
      ENSMUSP00000055605.5, ENSMUST00000055125.5
      Conserved Domains (1) summary
      cl38936
      Location:7 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80855423..80862038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513438.5 → XP_006513501.1  GTP-binding protein Di-Ras1 isoform X1

      See identical proteins and their annotated locations for XP_006513501.1

      UniProtKB/Swiss-Prot
      Q91Z61
      Conserved Domains (1) summary
      cl38936
      Location:7 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Z61.1 GenPept UniProtKB/Swiss-Prot:Q91Z61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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