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    Klhl29 kelch-like 29 [ Mus musculus (house mouse) ]

    Gene ID: 208439, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klhl29provided by MGI
    Official Full Name
    kelch-like 29provided by MGI
    Primary source
    MGI:MGI:2683857
    See related
    Ensembl:ENSMUSG00000020627 AllianceGenome:MGI:2683857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm68; Kbtbd9; mKIAA1921; A230106N14Rik
    Summary
    Is expressed in central nervous system and retina. Orthologous to human KLHL29 (kelch like family member 29). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 11.1), CNS E18 (RPKM 8.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A1.1; 12 2.28 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (5127465..5425682, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (5077465..5375682, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ATPase family, AAA domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_31466 Neighboring gene predicted gene, 23167 Neighboring gene RAB11B, member RAS oncogene family pseudogene Neighboring gene STARR-seq mESC enhancer starr_31469 Neighboring gene STARR-seq mESC enhancer starr_31470 Neighboring gene VISTA enhancer mm1338 Neighboring gene predicted gene, 51980 Neighboring gene STARR-seq mESC enhancer starr_31471 Neighboring gene RIKEN cDNA 2810032G03 gene Neighboring gene STARR-seq mESC enhancer starr_31472 Neighboring gene predicted gene, 32214

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    2. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 29
    Names
    kelch repeat and BTB (POZ) domain containing 9
    kelch repeat and BTB domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164493.1 → NP_001157965.1  kelch-like protein 29

      See identical proteins and their annotated locations for NP_001157965.1

      Status: VALIDATED

      Source sequence(s)
      AC131767, BC065168
      Consensus CDS
      CCDS49021.1
      UniProtKB/Swiss-Prot
      A6H646, Q80T74
      UniProtKB/TrEMBL
      A0A1W2P6N5
      Related
      ENSMUSP00000020958.9, ENSMUST00000020958.9
      Conserved Domains (7) summary
      smart00612
      Location:822 → 870
      Kelch; Kelch domain
      PHA03098
      Location:333 → 860
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:673 → 716
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:319 → 427
      BTB; BTB/POZ domain
      pfam01344
      Location:672 → 717
      Kelch_1; Kelch motif
      pfam07707
      Location:436 → 537
      BACK; BTB And C-terminal Kelch
      pfam11235
      Location:40 → 210
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      5127465..5425682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80T74.3 GenPept UniProtKB/Swiss-Prot:Q80T74

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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