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    Zfp143 zinc finger protein 143 [ Mus musculus (house mouse) ]

    Gene ID: 20841, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfp143provided by MGI
    Official Full Name
    zinc finger protein 143provided by MGI
    Primary source
    MGI:MGI:1277969
    See related
    Ensembl:ENSMUSG00000061079 AllianceGenome:MGI:1277969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SBF; Staf; Zfp79; pHZ-1; KRAB14; Znf143; Zfp80-rs1; D7Ertd805e
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of smooth muscle cell proliferation and positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.7), CNS E11.5 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E3; 7 57.7 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109660898..109694603)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110061689..110095396)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25636 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe) Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene predicted gene, 51505

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic organization, chromosomal mapping and promoter analysis of the mouse selenocysteine tRNA gene transcription-activating factor (mStaf) gene. Adachi K, et al. Biochem J, 2000 Feb 15. PMID 10657238, Free PMC Article
    2. Molecular cloning and characterization of the murine staf cDNA encoding a transcription activating factor for the selenocysteine tRNA gene in mouse mammary gland. Adachi K, et al. J Biol Chem, 1998 Apr 10. PMID 9535833
    3. ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function. Zhou Q, et al. Nat Commun, 2021 Jan 4. PMID 33397967, Free PMC Article
    4. Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11. Ngondo-Mbongo RP, et al. Nucleic Acids Res, 2013 Apr. PMID 23408857, Free PMC Article
    5. The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Carlson BA, et al. Biochem J, 2009 Feb 15. PMID 18973473, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway.
      Title: ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway.
    2. ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
      Title: ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
    3. Zfp143 regulates Nanog expression through modulation of Oct4 binding.
      Title: Zfp143 regulates Nanog through modulation of Oct4 binding.
    4. STAF influences selenoprotein expression by enhancing Sec tRNA gene synthesis in an organ-specific manner
      Title: The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 143
    Names
    mStaf
    selenocysteine tRNA gene transcription-activating factor
    zfp-143
    zinc finger protein 80, related sequence 1
    NP_001361547.1
    NP_001392700.1
    NP_001392701.1
    NP_033307.2
    XP_036008747.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374618.1 → NP_001361547.1  zinc finger protein 143 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244
      Consensus CDS
      CCDS90307.1
      UniProtKB/Swiss-Prot
      O70230, Q8BGB0, Q8CEI6, Q8CI27
      Related
      ENSMUSP00000081778.5, ENSMUST00000084727.11
      Conserved Domains (3) summary
      COG5048
      Location:251 → 424
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207 → 292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001405771.1 → NP_001392700.1  zinc finger protein 143 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244
      UniProtKB/Swiss-Prot
      O70230, Q8BGB0, Q8CEI6, Q8CI27

    3. NM_001405772.1 → NP_001392701.1  zinc finger protein 143 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244

    4. NM_009281.4 → NP_033307.2  zinc finger protein 143 isoform 2

      See identical proteins and their annotated locations for NP_033307.2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244
      Consensus CDS
      CCDS57580.1
      UniProtKB/Swiss-Prot
      O70230
      Related
      ENSMUSP00000148235.2, ENSMUST00000211798.2
      Conserved Domains (3) summary
      COG5048
      Location:250 → 423
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:206 → 291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109660898..109694603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152854.1 → XP_036008747.1  zinc finger protein 143 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:48 → 221
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:4 → 89
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:36 → 58
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70230.2 GenPept UniProtKB/Swiss-Prot:O70230

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