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    Stac src homology three (SH3) and cysteine rich domain [ Mus musculus (house mouse) ]

    Gene ID: 20840, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Stacprovided by MGI
    Official Full Name
    src homology three (SH3) and cysteine rich domainprovided by MGI
    Primary source
    MGI:MGI:1201400
    See related
    Ensembl:ENSMUSG00000032502 AllianceGenome:MGI:1201400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables transmembrane transporter binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Acts upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Located in T-tubule. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in lens. Orthologous to human STAC (SH3 and cysteine rich domain). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 13.7), cerebellum adult (RPKM 2.5) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stac in Genome Data Viewer
    Location:
    9 F3; 9 61.81 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (111386476..111519673, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111561437..111690588, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25292 Neighboring gene doublecortin-like kinase 3 Neighboring gene STARR-seq mESC enhancer starr_25295 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 36088 Neighboring gene predicted gene, 36034 Neighboring gene STARR-seq mESC enhancer starr_25298 Neighboring gene STARR-seq mESC enhancer starr_25299 Neighboring gene STARR-seq mESC enhancer starr_25300 Neighboring gene STARR-seq mESC enhancer starr_25301 Neighboring gene STARR-seq mESC enhancer starr_25302 Neighboring gene RIKEN cDNA 4930545L08 gene Neighboring gene predicted gene, 39430

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human and mouse chromosomal mapping of Stac, a neuron-specific protein with an SH3 domain. Kawai J, et al. Genomics, 1998 Jan 1. PMID 9465308
    2. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. Suzuki H, et al. Biochem Biophys Res Commun, 1996 Dec 24. PMID 8954993
    3. stac1 and stac2 genes define discrete and distinct subsets of dorsal root ganglia neurons. Legha W, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20736085
    4. A Ca(v)3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane. Rzhepetskyy Y, et al. Channels (Austin), 2016 Sep 2. PMID 27149520, Free PMC Article
    5. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130287, MGC130288

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 and cysteine-rich domain-containing protein
    Names
    SRC homology 3 and cysteine-rich domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324546.2 → NP_001311475.1  SH3 and cysteine-rich domain-containing protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC131794, AC161113, CT030122
      UniProtKB/TrEMBL
      Q3UYD4
      Conserved Domains (3) summary
      cd11833
      Location:146 → 198
      SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
      pfam16664
      Location:23 → 118
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:205 → 255
      SH3; Src Homology 3 domain superfamily

    2. NM_016853.4 → NP_058549.1  SH3 and cysteine-rich domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_058549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC131794, AC161113, CT030122
      Consensus CDS
      CCDS23586.1
      UniProtKB/Swiss-Prot
      P97306
      UniProtKB/TrEMBL
      Q3UPL9
      Related
      ENSMUSP00000035083.8, ENSMUST00000035083.8
      Conserved Domains (4) summary
      cd11833
      Location:290 → 342
      SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
      cd00029
      Location:109 → 160
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam16664
      Location:167 → 262
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:349 → 399
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      111386476..111519673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512016.5 → XP_006512079.1  SH3 and cysteine-rich domain-containing protein isoform X1

      Conserved Domains (4) summary
      cd11833
      Location:279 → 331
      SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
      cd00029
      Location:98 → 149
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam16664
      Location:156 → 204
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:338 → 388
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97306.1 GenPept UniProtKB/Swiss-Prot:P97306

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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