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    Ssrp1 structure specific recognition protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 20833, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ssrp1provided by MGI
    Official Full Name
    structure specific recognition protein 1provided by MGI
    Primary source
    MGI:MGI:107912
    See related
    Ensembl:ENSMUSG00000027067 AllianceGenome:MGI:107912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T160; Hmgox; Hmg1-rs1; Hmgi-rs3
    Summary
    Enables chromatin binding activity. Predicted to be involved in regulation of chromatin organization. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 88.2), liver E14 (RPKM 67.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 D; 2 49.45 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84867519..84877453)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85037120..85047114)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 3 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene RIKEN cDNA 4930443O20 gene Neighboring gene STARR-seq mESC enhancer starr_05013

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos. Cao S, et al. Mol Cell Biol, 2003 Aug. PMID 12861016, Free PMC Article
    2. The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure. Gariglio M, et al. Exp Cell Res, 1997 Nov 1. PMID 9367632
    3. Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters. Chen F, et al. Nucleic Acids Res, 2020 Oct 9. PMID 32894293, Free PMC Article
    4. Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation. Sandlesh P, et al. iScience, 2020 Jun 26. PMID 32498018, Free PMC Article
    5. Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. Sandlesh P, et al. PLoS One, 2018. PMID 29953487, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1.
      Title: Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1.
    2. Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
      Title: Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
    3. It has been demonstrated that FACT potentiates H2A.X-dependent signaling of DNA damage.
      Title: The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage.
    4. Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.
      Title: Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.
    5. FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage.
      Title: Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability.
    6. Ssrp1 appears to encode nonredundant and p53-independent functions that are essential for cell viability
      Title: The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FACT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FACT complex subunit SSRP1
    Names
    facilitates chromatin transcription complex subunit SSRP1
    recombination signal sequence recognition protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136081.3 → NP_001129553.1  FACT complex subunit SSRP1

      See identical proteins and their annotated locations for NP_001129553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 4. All five variants encode the same protein.
      Source sequence(s)
      AL935159, BX546441
      Consensus CDS
      CCDS38165.1
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
      UniProtKB/TrEMBL
      A2AW05
      Related
      ENSMUSP00000127058.2, ENSMUST00000168266.8
      Conserved Domains (2) summary
      COG5165
      Location:21 → 480
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      pfam00505
      Location:547 → 614
      HMG_box; HMG (high mobility group) box

    2. NM_001421071.1 → NP_001408000.1  FACT complex subunit SSRP1

      Status: VALIDATED

      Source sequence(s)
      AL935159, BX546441
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6

    3. NM_001421072.1 → NP_001408001.1  FACT complex subunit SSRP1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AL935159, BX546441
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6

    4. NM_001421073.1 → NP_001408002.1  FACT complex subunit SSRP1

      Status: VALIDATED

      Source sequence(s)
      AL935159, BX546441
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6

    5. NM_182990.5 → NP_892035.2  FACT complex subunit SSRP1

      See identical proteins and their annotated locations for NP_892035.2

      Status: VALIDATED

      Source sequence(s)
      AL935159, BX546441
      Consensus CDS
      CCDS38165.1
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
      UniProtKB/TrEMBL
      A2AW05
      Related
      ENSMUSP00000076971.7, ENSMUST00000077798.13
      Conserved Domains (2) summary
      COG5165
      Location:21 → 480
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      pfam00505
      Location:547 → 614
      HMG_box; HMG (high mobility group) box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84867519..84877453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239405.2 → XP_011237707.1  FACT complex subunit SSRP1 isoform X2

      Conserved Domains (1) summary
      COG5165
      Location:21 → 436
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08943.2 GenPept UniProtKB/Swiss-Prot:Q08943

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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