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    Mob3a MOB kinase activator 3A [ Mus musculus (house mouse) ]

    Gene ID: 208228, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mob3aprovided by MGI
    Official Full Name
    MOB kinase activator 3Aprovided by MGI
    Primary source
    MGI:MGI:3050117
    See related
    Ensembl:ENSMUSG00000003348 AllianceGenome:MGI:3050117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mobkl2a; A630029F06; 5330417K06Rik
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in positive regulation of protein phosphorylation and signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB3A (MOB kinase activator 3A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 74.2), spleen adult (RPKM 57.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80521087..80537845, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80685253..80701820, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51810 Neighboring gene BTB domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3899 Neighboring gene MAP kinase-interacting serine/threonine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80141015-80141203 Neighboring gene STARR-positive B cell enhancer ABC_E6884 Neighboring gene IZUMO family member 4 Neighboring gene adaptor-related protein complex 3, delta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E368

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 3A
    Names
    MOB1, Mps One Binder kinase activator-like 2A
    mob1 homolog 2A
    mps one binder kinase activator-like 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172457.2 → NP_766045.2  MOB kinase activator 3A

      See identical proteins and their annotated locations for NP_766045.2

      Status: PROVISIONAL

      Source sequence(s)
      BC058238
      Consensus CDS
      CCDS35982.1
      UniProtKB/Swiss-Prot
      Q3TBK2, Q8BSU7
      Related
      ENSMUSP00000003438.9, ENSMUST00000003438.11
      Conserved Domains (1) summary
      pfam03637
      Location:36 → 208
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80521087..80537845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155716.1 → XP_036011609.1  MOB kinase activator 3A isoform X1

      Conserved Domains (1) summary
      pfam03637
      Location:36 → 140
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSU7.1 GenPept UniProtKB/Swiss-Prot:Q8BSU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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