Alg1 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alg1provided by MGI
Official Full Name: ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferaseprovided by MGI
Primary source: MGI:MGI:2384774
See related: Ensembl:ENSMUSG00000039427 AllianceGenome:MGI:2384774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HMT1; HMAT1
Summary: Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 34.2), ovary adult (RPKM 29.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.51 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (5051410..5062773)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (5233621..5244909)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chitobiosyldiphosphodolichol beta-mannosyltransferase

Names: GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase); asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); asparagine-linked glycosylation protein 1 homolog; beta-1,4 mannosyltransferase

NP_663337.2

EC 2.4.1.142

XP_011244162.1

EC 2.4.1.142

XP_036015739.1

EC 2.4.1.142

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145362.2 → NP_663337.2 chitobiosyldiphosphodolichol beta-mannosyltransferase

See identical proteins and their annotated locations for NP_663337.2

Status: VALIDATED

Source sequence(s)

AK145871, BE948597

Consensus CDS

CCDS49753.1

UniProtKB/Swiss-Prot

Q3UKT8, Q921Q3

Related

ENSMUSP00000097770.3, ENSMUST00000100196.9

Conserved Domains (2) summary

cd03816
Location:33 → 461

GT1_ALG1_like; This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and ...

PLN02275
Location:29 → 424

PLN02275; transferase, transferring glycosyl groups

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

5051410..5062773

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159846.1 → XP_036015739.1 chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X1

Conserved Domains (1) summary

cd03816
Location:33 → 515

GT33_ALG1-like; chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins
XM_011245860.3 → XP_011244162.1 chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X2

Conserved Domains (1) summary

cl10013
Location:24 → 306

Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology