Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srmsprovided by MGI
Official Full Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesprovided by MGI
Primary source: MGI:MGI:101865
See related: Ensembl:ENSMUSG00000027579 AllianceGenome:MGI:101865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: srm; A230069J08Rik
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including innate immune response; peptidyl-tyrosine autophosphorylation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including brain; gut; integumental system; liver and biliary system; and reproductive system. Orthologous to human SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 3.6), testis adult (RPKM 3.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.62 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180847356..180854964, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (181205563..181213245, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
Title: Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

BB196245 (e-PCR)
- UniSTS:207456

Srms (e-PCR), detects polymorphism
- UniSTS:144508

Srms (e-PCR), detects polymorphism
- UniSTS:144509

D26186 (e-PCR)
- UniSTS:124817

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase Srms

Names: PTK70

NP_035611.3

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011481.3 → NP_035611.3 tyrosine-protein kinase Srms

See identical proteins and their annotated locations for NP_035611.3

Status: VALIDATED

Source sequence(s)

AK038866, AK049582

Consensus CDS

CCDS17204.1

UniProtKB/Swiss-Prot

Q62270, Q62360, Q923M5

UniProtKB/TrEMBL

Q0VBH4

Related

ENSMUSP00000016498.5, ENSMUST00000016498.5

Conserved Domains (4) summary

cd05148
Location:238 → 498

PTKc_Srm_Brk; Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk)

cd10360
Location:134 → 212

SH2_Srm; Src homology 2 (SH2) domain found in Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (srm)

smart00221
Location:246 → 495

STYKc; Protein kinase; unclassified specificity

cl17036
Location:70 → 124

SH3; Src Homology 3 domain superfamily