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    Gtpbp10 GTP-binding protein 10 (putative) [ Mus musculus (house mouse) ]

    Gene ID: 207704, updated on 21-Apr-2024

    Summary

    Official Symbol
    Gtpbp10provided by MGI
    Official Full Name
    GTP-binding protein 10 (putative)provided by MGI
    Primary source
    MGI:MGI:2385599
    See related
    Ensembl:ENSMUSG00000040464 AllianceGenome:MGI:2385599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930545J22Rik
    Summary
    Predicted to enable GTP binding activity. Predicted to act upstream of or within ribosome biogenesis. Located in mitochondrion. Is expressed in cardiovascular system; genitourinary system; gut; lung; and skin. Orthologous to human GTPBP10 (GTP binding protein 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 4.3) and 21 other tissues See more
    Orthologs
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    Genomic context

    Location:
    5 A1; 5 3.02 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (5587454..5609541, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (5537454..5559541, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30325 Neighboring gene claudin 12 Neighboring gene family with sequence similarity 237, member B Neighboring gene cilia and flagella associated protein 69

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC30495

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357031.1NP_001343960.1  GTP-binding protein 10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC026813, AC068663
      Conserved Domains (1) summary
      cl25666
      Location:15296
      HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
    2. NM_001357032.1NP_001343961.1  GTP-binding protein 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive alternate exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC026813, AC068663
      UniProtKB/TrEMBL
      F8WHJ2
      Related
      ENSMUSP00000113648.3, ENSMUST00000119521.8
      Conserved Domains (2) summary
      cd01898
      Location:108270
      Obg; Obg GTPase
      pfam01018
      Location:16106
      GTP1_OBG; GTP1/OBG
    3. NM_153116.2NP_694756.1  GTP-binding protein 10 isoform 1.

      See identical proteins and their annotated locations for NP_694756.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC026813, AC068663, AK160252
      Consensus CDS
      CCDS39006.1
      UniProtKB/Swiss-Prot
      Q8K013
      Related
      ENSMUSP00000111101.3, ENSMUST00000115441.9
      Conserved Domains (3) summary
      cd01898
      Location:149343
      Obg; Obg GTPase
      TIGR02729
      Location:15343
      Obg_CgtA; Obg family GTPase CgtA
      pfam01018
      Location:15145
      GTP1_OBG; GTP1/OBG

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      5587454..5609541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)