Dtx4 deltex 4, E3 ubiquitin ligase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dtx4provided by MGI
Official Full Name: deltex 4, E3 ubiquitin ligaseprovided by MGI
Primary source: MGI:MGI:2672905
See related: Ensembl:ENSMUSG00000039982 AllianceGenome:MGI:2672905
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RNF155; D930042H13
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in Notch signaling pathway and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human DTX4 (deltex E3 ubiquitin ligase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 16.0), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (12443700..12479509, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (12466329..12502179, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results indicate that DTX4 stable knockdown inhibits adipogenesis of 3T3-L1 cells through inhibiting C/EBPalpha and PPARgamma, arresting mitotic clonal expansion and regulating Wnt signaling pathway.
Title: E3 ubiquitin ligase DTX4 is required for adipogenic differentiation in 3T3-L1 preadipocytes cell line.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI449438 (e-PCR)
- UniSTS:164651

AI030803 (e-PCR)
- UniSTS:261492

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase DTX4

Names: RING-type E3 ubiquitin transferase DTX4; deltex 4 homolog; deltex4; protein deltex-4

NP_001388321.1

EC 2.3.2.27

NP_766030.3

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401392.1 → NP_001388321.1 E3 ubiquitin-protein ligase DTX4 isoform 2

Status: VALIDATED

Source sequence(s)

AC151730
NM_172442.3 → NP_766030.3 E3 ubiquitin-protein ligase DTX4 isoform 1

See identical proteins and their annotated locations for NP_766030.3

Status: VALIDATED

Source sequence(s)

BC058647, BU705490, CA328050, CF537541, CN525673

Consensus CDS

CCDS29631.1

UniProtKB/Swiss-Prot

Q6IS30, Q6PDK8, Q8BID3

Related

ENSMUSP00000040229.8, ENSMUST00000045521.9

Conserved Domains (4) summary

smart00678
Location:8 → 86

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd09633
Location:473 → 605

Deltex_C; Domain found at the C-terminus of deltex-like

cd00162
Location:405 → 466

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam02825
Location:90 → 144

WWE; WWE domain