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    Strbp spermatid perinuclear RNA binding protein [ Mus musculus (house mouse) ]

    Gene ID: 20744, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Strbpprovided by MGI
    Official Full Name
    spermatid perinuclear RNA binding proteinprovided by MGI
    Primary source
    MGI:MGI:104626
    See related
    Ensembl:ENSMUSG00000026915 AllianceGenome:MGI:104626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spnr; 6430510M02Rik; C230082I21Rik
    Summary
    Enables double-stranded RNA binding activity; microtubule binding activity; and single-stranded RNA binding activity. Acts upstream of or within mechanosensory behavior and spermatid development. Located in manchette. Is expressed in central nervous system; dorsal root ganglion; metanephros; sensory organ; and trigeminal nerve. Orthologous to human STRBP (spermatid perinuclear RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 9.7), cortex adult (RPKM 9.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 24.19 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37459880..37593890, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37569868..37703878, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 Neighboring gene nucleoporin 37 pseudogene Neighboring gene G protein-coupled receptor 21 Neighboring gene zinc finger protein 609 pseudogene Neighboring gene microRNA 5128 Neighboring gene STARR-positive B cell enhancer ABC_E9511 Neighboring gene STARR-seq mESC enhancer starr_04315 Neighboring gene STARR-positive B cell enhancer ABC_E5909 Neighboring gene DENN domain containing 1A Neighboring gene crumbs family member 2 Neighboring gene STARR-seq mESC enhancer starr_04318 Neighboring gene STARR-seq mESC enhancer starr_04319 Neighboring gene STARR-seq mESC enhancer starr_04321 Neighboring gene predicted gene, 46736 Neighboring gene LIM homeobox protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. Pires-daSilva A, et al. Dev Biol, 2001 May 15. PMID 11336498
    2. Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system. Stoykova A, et al. Dev Dyn, 1998 Jun. PMID 9626495
    3. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. Schumacher JM, et al. J Cell Biol, 1995 May. PMID 7744952, Free PMC Article
    4. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Schumacher JM, et al. Biol Reprod, 1998 Jul. PMID 9674995
    5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spermatid perinuclear RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355259.1 → NP_001342188.1  spermatid perinuclear RNA-binding protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AL953890, BX545905
      Consensus CDS
      CCDS38118.1
      UniProtKB/Swiss-Prot
      Q62262, Q91WM1
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    2. NM_001379314.1 → NP_001366243.1  spermatid perinuclear RNA-binding protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 2, and 5, encodes isoform a.
      Source sequence(s)
      AL805959, AL953890, BX545905
      UniProtKB/Swiss-Prot
      Q62262, Q91WM1
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    3. NM_001379315.1 → NP_001366244.1  spermatid perinuclear RNA-binding protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, and 4, encodes isoform a.
      Source sequence(s)
      AL805959, AL953890, BX545905
      UniProtKB/Swiss-Prot
      Q62262, Q91WM1
      Related
      ENSMUSP00000072047.6, ENSMUST00000072186.12
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    4. NM_001379316.1 → NP_001366245.1  spermatid perinuclear RNA-binding protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AL805959, AL953890, BX545905
      Conserved Domains (3) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    5. NM_009261.4 → NP_033287.2  spermatid perinuclear RNA-binding protein isoform a

      See identical proteins and their annotated locations for NP_033287.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AL953890, BX545905
      Consensus CDS
      CCDS38118.1
      UniProtKB/Swiss-Prot
      Q62262, Q91WM1
      Related
      ENSMUSP00000028279.4, ENSMUST00000028279.10
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    RNA

    1. NR_166612.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953890, BX545905

    2. NR_166614.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL805959, AL953890, BX545905

    3. NR_166615.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL805959, AL953890, BX545905

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      37459880..37593890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160012.1 → XP_036015905.1  spermatid perinuclear RNA-binding protein isoform X1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    2. XM_036160033.1 → XP_036015926.1  spermatid perinuclear RNA-binding protein isoform X3

      Conserved Domains (3) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    3. XM_036160005.1 → XP_036015898.1  spermatid perinuclear RNA-binding protein isoform X1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    4. XM_011239043.4 → XP_011237345.1  spermatid perinuclear RNA-binding protein isoform X1

      See identical proteins and their annotated locations for XP_011237345.1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    5. XM_036160013.1 → XP_036015906.1  spermatid perinuclear RNA-binding protein isoform X1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    6. XM_036160022.1 → XP_036015915.1  spermatid perinuclear RNA-binding protein isoform X1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    7. XM_036160018.1 → XP_036015911.1  spermatid perinuclear RNA-binding protein isoform X1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    8. XM_036160011.1 → XP_036015904.1  spermatid perinuclear RNA-binding protein isoform X1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    9. XM_036160015.1 → XP_036015908.1  spermatid perinuclear RNA-binding protein isoform X1

      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    10. XM_030248990.1 → XP_030104850.1  spermatid perinuclear RNA-binding protein isoform X3

      Related
      ENSMUSP00000139145.2, ENSMUST00000183690.8
      Conserved Domains (3) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    11. XM_017316823.2 → XP_017172312.1  spermatid perinuclear RNA-binding protein isoform X2

      UniProtKB/Swiss-Prot
      Q62262, Q91WM1
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    12. XM_036160024.1 → XP_036015917.1  spermatid perinuclear RNA-binding protein isoform X2

      UniProtKB/Swiss-Prot
      Q62262, Q91WM1
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    13. XM_017316820.3 → XP_017172309.1  spermatid perinuclear RNA-binding protein isoform X2

      UniProtKB/Swiss-Prot
      Q62262, Q91WM1
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    RNA

    1. XR_003951764.1 RNA Sequence

    2. XR_001781603.2 RNA Sequence

    3. XR_866011.3 RNA Sequence

    4. XR_866010.3 RNA Sequence

    5. XR_866009.3 RNA Sequence

    6. XR_001781604.2 RNA Sequence

    7. XR_003951765.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176932.2: Suppressed sequence

      Description
      NM_176932.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WM1.1 GenPept UniProtKB/Swiss-Prot:Q91WM1

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