Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb5provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 5provided by MGI
Primary source: MGI:MGI:109579
See related: Ensembl:ENSMUSG00000067006 AllianceGenome:MGI:109579
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PI-5; Spi7; Maspin; ovalbumin; 1110036M19Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human SERPINB5 (serpin family B member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 5.5), colon adult (RPKM 2.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (106788905..106811078)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (106861175..106883348)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study to recognize the potential implication of maspin in the pathophysiology of asthma
Title: Increased extracellular maspin levels after mechanical compression in vitro or allergen challenge in vivo.
model of apoptosis in which maspin binds to cardiolipin, displaces cytochrome c from the membrane, and facilitates its release to the cytoplasm.
Title: Maspin binds to cardiolipin in mitochondria and triggers apoptosis.
maspin is a powerful context-dependent tumor suppressor.
Title: An Essential Role of Maspin in Embryogenesis and Tumor Suppression.
these data indicate that SerpinB5 expression and phosphorylation are developmentally regulated. In vitro analyses indicate that SerpinB5 phosphorylation is regulated by EGFR ligands, but EGF appears to be the only able to induce SerpinB5 nuclear localization.
Title: EGFR Signaling Regulates Maspin/SerpinB5 Phosphorylation and Nuclear Localization in Mammary Epithelial Cells.
perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression
Title: Maspin is not required for embryonic development or tumour suppression.
evidence demonstrates that D(346) is a critical cis-element in maspin sequence that determines the molecular context and subcellular localization of maspin.
Title: Identification of an intrinsic determinant critical for maspin subcellular localization and function.
a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth.
Title: Tumor-suppressive maspin functions as a reactive oxygen species scavenger: importance of cysteine residues.
results suggest that maspin, a tumor suppressor, may play an important role in embryo implantation
Title: Expression of maspin in the early pregnant mouse endometrium and its role during embryonic implantation.
The nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo.
Title: Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis.
SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma
Title: SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI462524 (e-PCR)
- UniSTS:178448

AI646751 (e-PCR)
- UniSTS:178451

Serpinb5 (e-PCR), detects polymorphism
- UniSTS:144499

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serpin B5

Names: peptidase inhibitor 5; protease inhibitor 5; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serine (or cysteine) proteinase inhibitor, clade B, member 5; serine protease inhibitor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360853.1 → NP_001347782.1 serpin B5 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC025047, AC163626, AK136532, U54705

Consensus CDS

CCDS35684.1

UniProtKB/Swiss-Prot

P70124, Q3ULZ0

Related

ENSMUSP00000108350.2, ENSMUST00000112730.8

Conserved Domains (1) summary

cd02057
Location:4 → 375

maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...
NM_001360854.1 → NP_001347783.1 serpin B5 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC025047, AC163626

Conserved Domains (1) summary

cl00137
Location:1 → 204

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
NM_009257.4 → NP_033283.1 serpin B5 isoform a

See identical proteins and their annotated locations for NP_033283.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC025047, AC163626, AK136532

Consensus CDS

CCDS35684.1

UniProtKB/Swiss-Prot

P70124, Q3ULZ0

Related

ENSMUSP00000083908.7, ENSMUST00000086701.13

Conserved Domains (1) summary

cd02057
Location:4 → 375

maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...