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    Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b [ Mus musculus (house mouse) ]

    Gene ID: 20708, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Serpinb6bprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6bprovided by MGI
    Primary source
    MGI:MGI:894688
    See related
    Ensembl:ENSMUSG00000042842 AllianceGenome:MGI:894688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NK13; Spi12; ovalbumin
    Summary
    Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; eye surface region; gonad; lung; and vagus ganglion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 59.9), lung adult (RPKM 11.5) and 5 other tissues See more
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    Genomic context

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    Location:
    13 A3.2; 13 13.78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33140797..33163050)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32956811..32979067)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence M71 enhancer Neighboring gene predicted gene, 35899 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1c Neighboring gene STARR-positive B cell enhancer ABC_E7220 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:33096570-33096679 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9 Neighboring gene predicted gene, 36181 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9b Neighboring gene predicted gene, 36099

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization. Yu HF, et al. J Cell Mol Med, 2020 Jun. PMID 32391984, Free PMC Article
    2. Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A. Kaiserman D, et al. J Biol Chem, 2014 Mar 28. PMID 24505135, Free PMC Article
    3. Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals. Rutitzky LI, et al. J Immunol, 2005 Jan 1. PMID 15611268
    4. Expression of serpinb6 serpins in germ and somatic cells of mouse gonads. Charron Y, et al. Mol Reprod Dev, 2006 Jan. PMID 16175637
    5. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). Sun J, et al. J Biol Chem, 1997 Jun 13. PMID 9182575

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization.
      Title: Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gonad development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of serine protease inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine (or cysteine) proteinase inhibitor, clade B, member 6b
    Names
    serine protease inhibitor 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011454.2 → NP_035584.1  serine (or cysteine) proteinase inhibitor, clade B, member 6b

      See identical proteins and their annotated locations for NP_035584.1

      Status: VALIDATED

      Source sequence(s)
      AI448094, BB065179, DV058071, U96707
      Consensus CDS
      CCDS26430.1
      UniProtKB/TrEMBL
      O08804
      Related
      ENSMUSP00000105922.3, ENSMUST00000110293.9
      Conserved Domains (1) summary
      cl38926
      Location:1 → 377
      serpin; SERine Proteinase INhibitors (serpin) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      33140797..33163050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516621.5 → XP_006516684.1  serine (or cysteine) proteinase inhibitor, clade B, member 6b isoform X1

      See identical proteins and their annotated locations for XP_006516684.1

      UniProtKB/TrEMBL
      O08804
      Conserved Domains (1) summary
      cl38926
      Location:1 → 377
      serpin; SERine Proteinase INhibitors (serpin) family

    2. XM_006516622.5 → XP_006516685.3  serine (or cysteine) proteinase inhibitor, clade B, member 6b isoform X2

      Conserved Domains (1) summary
      cl38926
      Location:44 → 366
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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