Serpinb9b serine (or cysteine) peptidase inhibitor, clade B, member 9b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb9bprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 9bprovided by MGI
Primary source: MGI:MGI:894668
See related: Ensembl:ENSMUSG00000021403 AllianceGenome:MGI:894668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: R86; Spi10; SPI-CI; ovalbumin; 1600019A21Rik
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protease binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within T cell mediated cytotoxicity. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and extracellular space. Is expressed in atrioventricular canal; atrioventricular valve; endocardial cushion; interventricular septum; and mitral valve. Orthologous to human SERPINB9 (serpin family B member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward placenta adult (RPKM 89.0) See more
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Genomic context

Location:: 13 A3.3; 13 13.79 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (33211397..33224571)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (33027414..33040588)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

evidence that colon carcinoma cell lines resist membranolysis dependent on SPI-6 but also requires expression of SPI-CI
Title: SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in protection from natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine (or cysteine) proteinase inhibitor, clade B, member 9b

Names: serine protease inhibitor 10; serine proteinase inhibitor R86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011452.3 → NP_035582.1 serine (or cysteine) proteinase inhibitor, clade B, member 9b

See identical proteins and their annotated locations for NP_035582.1

Status: VALIDATED

Source sequence(s)

BG089710, U96705

Consensus CDS

CCDS26432.1

UniProtKB/TrEMBL

O08802, Q3TJ69, Q6P217, Q9DAV6

Related

ENSMUSP00000006392.3, ENSMUST00000006392.3

Conserved Domains (1) summary

cl00137
Location:4 → 377

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...