Sox14 SRY (sex determining region Y)-box 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sox14provided by MGI
Official Full Name: SRY (sex determining region Y)-box 14provided by MGI
Primary source: MGI:MGI:98362
See related: Ensembl:ENSMUSG00000053747 AllianceGenome:MGI:98362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and chromatin binding activity. Acts upstream of or within entrainment of circadian clock; regulation of neuron migration; and visual perception. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and thymus. Orthologous to human SOX14 (SRY-box transcription factor 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 52.11 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (99756159..99758223, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (99874106..99876170, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that Sox14 is critical for Kisspeptin-neuronal development, which likely underlies the infertility of Sox14-KO mice.
Title: Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators.
Association learning is unaffected by Sox14(+) neuron elimination in the cerebellar nuclei.
Title: Sox14 Is Required for a Specific Subset of Cerebello-Olivary Projections.
This study demonistrated that SOX14 is to orchestrate the correct distribution of neurons among the different nuclei of the network and how Sox14 expression is required both to ensure robustness in circadian entrainment and for masking of motor activity.
Title: Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sox14 (e-PCR), detects polymorphism
- UniSTS:158762

Sox14 (e-PCR), detects polymorphism
- UniSTS:144485

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor SOX-14

Names: SRY-box containing gene 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011440.1 → NP_035570.1 transcription factor SOX-14

See identical proteins and their annotated locations for NP_035570.1

Status: VALIDATED

Source sequence(s)

BC055767, BC100555

Consensus CDS

CCDS57695.1

UniProtKB/Swiss-Prot

Q04892, Q9JLC9, Q9JLD0, Q9QXU4

UniProtKB/TrEMBL

Q3UUP3

Related

ENSMUSP00000091310.6, ENSMUST00000054819.10

Conserved Domains (2) summary

cd01388
Location:7 → 78

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam12336
Location:77 → 118

SOXp; SOX transcription factor