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    Snrpb small nuclear ribonucleoprotein B [ Mus musculus (house mouse) ]

    Gene ID: 20638, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Snrpbprovided by MGI
    Official Full Name
    small nuclear ribonucleoprotein Bprovided by MGI
    Primary source
    MGI:MGI:98342
    See related
    Ensembl:ENSMUSG00000027404 AllianceGenome:MGI:98342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMB; SM-B; SM11; SNRNP-B
    Summary
    Enables histone pre-mRNA DCP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to act upstream of or within protein methylation. Located in cytoplasm and nucleus. Part of histone pre-mRNA 3'end processing complex. Is expressed in several structures, including branchial arch; central nervous system; limb; maxillary process; and sensory organ. Human ortholog(s) of this gene implicated in cerebrocostomandibular syndrome and mixed connective tissue disease. Orthologous to human SNRPB (small nuclear ribonucleoprotein polypeptides B and B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 137.1), adrenal adult (RPKM 133.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 63.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130013560..130031184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130171636..130179382, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene expressed sequence AU015228 Neighboring gene transglutaminase 6 Neighboring gene STARR-positive B cell enhancer ABC_E2047 Neighboring gene transmembrane channel-like gene family 2 Neighboring gene STARR-seq mESC enhancer starr_05689 Neighboring gene STARR-seq mESC enhancer starr_05690 Neighboring gene STARR-positive B cell enhancer ABC_E643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130100530-130100713 Neighboring gene small nucleolar RNA, C/D box 110 Neighboring gene NOP56 ribonucleoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer. Liu N, et al. Med Oncol, 2021 Apr 9. PMID 33835288
    2. Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos. Turner BRH, et al. Dev Dyn, 2023 Feb. PMID 36058892, Free PMC Article
    3. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Larsson SH, et al. Cell, 1995 May 5. PMID 7736591
    4. Comparison of the Drosophila melanogaster, human and murine Sm B cDNAs: evolutionary conservation. Brunet C, et al. Gene, 1993 Feb 28. PMID 7680326
    5. The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site. Griffith AJ, et al. Gene, 1992 May 15. PMID 1376292

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos.
      Title: Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos.
    2. Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.
      Title: Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.
    3. SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer.
      Title: SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U2 snRNP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone pre-mRNA DCP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables snRNP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U7 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone pre-mRNA 3'end processing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small nuclear ribonucleoprotein-associated protein B
    Names
    sm protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412650.1 → NP_001399579.1  small nuclear ribonucleoprotein-associated protein B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL833804

    2. NM_001412651.1 → NP_001399580.1  small nuclear ribonucleoprotein-associated protein B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL833804

    3. NM_001412652.1 → NP_001399581.1  small nuclear ribonucleoprotein-associated protein B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL833804

    4. NM_001412653.1 → NP_001399582.1  small nuclear ribonucleoprotein-associated protein B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL833804

    5. NM_001412654.1 → NP_001399583.1  small nuclear ribonucleoprotein-associated protein B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL833804

    6. NM_001412655.1 → NP_001399584.1  small nuclear ribonucleoprotein-associated protein B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL833804

    7. NM_001412656.1 → NP_001399585.1  small nuclear ribonucleoprotein-associated protein B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL833804

    8. NM_001412657.1 → NP_001399586.1  small nuclear ribonucleoprotein-associated protein B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL833804

    9. NM_001412658.1 → NP_001399587.1  small nuclear ribonucleoprotein-associated protein B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL833804

    10. NM_001412659.1 → NP_001399588.1  small nuclear ribonucleoprotein-associated protein B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL833804

    11. NM_001420982.1 → NP_001407911.1  small nuclear ribonucleoprotein-associated protein B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL833804

    12. NM_009225.3 → NP_033251.1  small nuclear ribonucleoprotein-associated protein B isoform 1

      See identical proteins and their annotated locations for NP_033251.1

      Status: VALIDATED

      Source sequence(s)
      AL833804
      Consensus CDS
      CCDS16735.1
      UniProtKB/Swiss-Prot
      P27048, Q3UJT1
      UniProtKB/TrEMBL
      O70499
      Related
      ENSMUSP00000099488.5, ENSMUST00000103199.9
      Conserved Domains (1) summary
      cd01717
      Location:5 → 83
      Sm_B; Sm protein B

    RNA

    1. NR_182019.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL833804

    2. NR_182020.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL833804
      Related
      ENSMUST00000147570.3

    3. NR_182021.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL833804

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130013560..130031184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159932.1 → XP_036015825.1  small nuclear ribonucleoprotein-associated protein B isoform X1

      UniProtKB/Swiss-Prot
      P27048, Q3UJT1
      UniProtKB/TrEMBL
      O70499
      Conserved Domains (1) summary
      cd01717
      Location:5 → 83
      Sm_B; Sm protein B
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27048.1 GenPept UniProtKB/Swiss-Prot:P27048

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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