Snap91 synaptosomal-associated protein 91 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snap91provided by MGI
Official Full Name: synaptosomal-associated protein 91provided by MGI
Primary source: MGI:MGI:109132
See related: Ensembl:ENSMUSG00000033419 AllianceGenome:MGI:109132
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 91kDa; AP180; F1-20; mKIAA0656
Summary: Enables 1-phosphatidylinositol binding activity; clathrin heavy chain binding activity; and protein kinase binding activity. Involved in clathrin coat assembly; neurotransmitter secretion; and synaptic vesicle budding from presynaptic endocytic zone membrane. Located in presynaptic endocytic zone and presynaptic endosome. Is extrinsic component of endosome membrane and extrinsic component of presynaptic endocytic zone membrane. Is expressed in several structures, including central nervous system; gut; limb; peripheral nervous system ganglion; and urinary system. Orthologous to human SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 52.2), CNS E18 (RPKM 48.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.1; 9 46.58 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (86647976..86762766, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (86765923..86880734, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
Title: AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
Confinement within the presynaptic bouton is mediated in part by synaptic vesicle protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins.
Title: Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.
The clathrin assembly role of AP180 is mediated by a long disordered C-terminal assembly domain.
Title: The ∼ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables clathrin adaptor activity	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables clathrin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables clathrin heavy chain binding	ISO Inferred from Sequence Orthology more info
enables inositol hexakisphosphate binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin coat assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in clathrin coat assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of terminal button organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IC Inferred by Curator more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
is_active_in clathrin-coated pit	IBA Inferred from Biological aspect of Ancestor more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of presynaptic endocytic zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of presynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic endocytic zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic endosome	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: clathrin coat assembly protein AP180

Names: 91 kDa synaptosomal-associated protein; clathrin coat-associated protein AP180; phosphoprotein F1-20; synaptosomal-associated protein, 91 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277982.2 → NP_001264911.1 clathrin coat assembly protein AP180 isoform 3

See identical proteins and their annotated locations for NP_001264911.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate splice site and lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter and lacks two segments in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC156831, BC031773, CT025628

UniProtKB/TrEMBL

E9QQ05

Conserved Domains (2) summary

PHA03247
Location:475 → 862

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
NM_001277983.1 → NP_001264912.1 clathrin coat assembly protein AP180 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks four in-frame exons in the coding region, compared to variant 1. The resulting isoform (4) is shorter and lacks four internal segments, compared to isoform 1.

Source sequence(s)

BC052454, CA315349

Consensus CDS

CCDS72289.1

UniProtKB/TrEMBL

E9Q9A3, Q3UI39

Related

ENSMUSP00000096096.4, ENSMUST00000098495.10

Conserved Domains (1) summary

pfam07651
Location:19 → 284

ANTH; ANTH domain
NM_001277985.1 → NP_001264914.1 clathrin coat assembly protein AP180 isoform 5

See identical proteins and their annotated locations for NP_001264914.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks multiple exons in the coding region, compared to variant 1. The The resulting isoform (5) lacks two internal segments and has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK159570, BC052454, CA315349, CA560936, CN692883

Consensus CDS

CCDS72288.1

UniProtKB/TrEMBL

Q3TWS4

Related

ENSMUSP00000074095.6, ENSMUST00000074501.12

Conserved Domains (1) summary

pfam07651
Location:19 → 284

ANTH; ANTH domain
NM_001277986.1 → NP_001264915.1 clathrin coat assembly protein AP180 isoform 2

See identical proteins and their annotated locations for NP_001264915.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC031773, BC052454, CA315349

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (1) summary

pfam07651
Location:19 → 284

ANTH; ANTH domain
NM_001357768.1 → NP_001344697.1 clathrin coat assembly protein AP180 isoform 6

Status: VALIDATED

Source sequence(s)

AC156831, CT025628

UniProtKB/TrEMBL

Q7TT20, Q8CHE0

Conserved Domains (1) summary

cl26464
Location:201 → 617

Atrophin-1; Atrophin-1 family
NM_001357770.1 → NP_001344699.1 clathrin coat assembly protein AP180 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 8 both encode the same isoform (1).

Source sequence(s)

AC156831, CT025628

UniProtKB/Swiss-Prot

Q61547, Q61548, Q8K0D4

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

pfam07651
Location:21 → 284

ANTH; ANTH domain

cl26464
Location:475 → 891

Atrophin-1; Atrophin-1 family
NM_001357772.1 → NP_001344701.1 clathrin coat assembly protein AP180 isoform 7

Status: VALIDATED

Source sequence(s)

AC156831, CT025628

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

pfam07651
Location:21 → 284

ANTH; ANTH domain

cl26464
Location:439 → 850

Atrophin-1; Atrophin-1 family
NM_001420279.1 → NP_001407208.1 clathrin coat assembly protein AP180 isoform 8

Status: VALIDATED

Source sequence(s)

AC156831, CT025628
NM_013669.2 → NP_038697.1 clathrin coat assembly protein AP180 isoform 1

See identical proteins and their annotated locations for NP_038697.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 8 both encode the same isoform (1).

Source sequence(s)

BC052454, CA315349

UniProtKB/Swiss-Prot

Q61547, Q61548, Q8K0D4

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

pfam07651
Location:21 → 284

ANTH; ANTH domain

cl26464
Location:475 → 891

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

86647976..86762766 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244159.2 → XP_030100019.1 clathrin coat assembly protein AP180 isoform X20

Conserved Domains (2) summary

PHA03247
Location:384 → 574

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_017313237.3 → XP_017168726.1 clathrin coat assembly protein AP180 isoform X16

UniProtKB/TrEMBL

Q3UI39

Conserved Domains (2) summary

PHA03247
Location:475 → 839

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_006510900.4 → XP_006510963.1 clathrin coat assembly protein AP180 isoform X10

See identical proteins and their annotated locations for XP_006510963.1

UniProtKB/TrEMBL

E9QQ05

Related

ENSMUSP00000046189.7, ENSMUST00000036347.13

Conserved Domains (2) summary

PHA03247
Location:475 → 862

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_030244158.2 → XP_030100018.1 clathrin coat assembly protein AP180 isoform X14

UniProtKB/TrEMBL

E9QQ05

Conserved Domains (2) summary

PHA03247
Location:475 → 845

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_006510898.5 → XP_006510961.1 clathrin coat assembly protein AP180 isoform X8

UniProtKB/TrEMBL

E9QQ05

Conserved Domains (2) summary

PHA03247
Location:475 → 867

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_006510897.3 → XP_006510960.1 clathrin coat assembly protein AP180 isoform X6

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (1) summary

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_030244156.2 → XP_030100016.1 clathrin coat assembly protein AP180 isoform X4

UniProtKB/TrEMBL

A0A5F8MPL3, E9QLK9

Conserved Domains (2) summary

PHA03247
Location:468 → 884

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_006510904.5 → XP_006510967.1 clathrin coat assembly protein AP180 isoform X19

Conserved Domains (2) summary

PHA03247
Location:384 → 598

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_036154753.1 → XP_036010646.1 clathrin coat assembly protein AP180 isoform X17

UniProtKB/TrEMBL

Q3UI39

Conserved Domains (2) summary

PHA03247
Location:468 → 828

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:21 → 282

ANTH; ANTH domain
XM_030244157.2 → XP_030100017.1 clathrin coat assembly protein AP180 isoform X11

UniProtKB/TrEMBL

Q3UI39

Conserved Domains (2) summary

PHA03247
Location:468 → 856

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_030244155.2 → XP_030100015.1 clathrin coat assembly protein AP180 isoform X4

UniProtKB/TrEMBL

A0A5F8MPL3, E9QLK9

Related

ENSMUSP00000159021.2, ENSMUST00000239074.2

Conserved Domains (2) summary

PHA03247
Location:468 → 884

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_036154751.1 → XP_036010644.1 clathrin coat assembly protein AP180 isoform X9

UniProtKB/TrEMBL

Q3UI39

Conserved Domains (2) summary

PHA03247
Location:473 → 861

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:21 → 282

ANTH; ANTH domain
XM_036154749.1 → XP_036010642.1 clathrin coat assembly protein AP180 isoform X3

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

PHA03247
Location:473 → 884

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:21 → 282

ANTH; ANTH domain
XM_006510903.5 → XP_006510966.1 clathrin coat assembly protein AP180 isoform X18

Conserved Domains (2) summary

PHA03247
Location:386 → 600

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_036154750.1 → XP_036010643.1 clathrin coat assembly protein AP180 isoform X5

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

PHA03247
Location:470 → 881

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:21 → 282

ANTH; ANTH domain
XM_006510896.5 → XP_006510959.1 clathrin coat assembly protein AP180 isoform X2

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

PHA03247
Location:470 → 886

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_006510901.5 → XP_006510964.1 clathrin coat assembly protein AP180 isoform X12

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

PHA03247
Location:439 → 855

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_006510902.5 → XP_006510965.1 clathrin coat assembly protein AP180 isoform X15

UniProtKB/TrEMBL

E9QLK9

Conserved Domains (2) summary

PHA03247
Location:475 → 835

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain
XM_036154752.1 → XP_036010645.1 clathrin coat assembly protein AP180 isoform X13

UniProtKB/TrEMBL

Q3UI39

Conserved Domains (2) summary

PHA03247
Location:475 → 845

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:21 → 282

ANTH; ANTH domain
XM_006510899.5 → XP_006510962.1 clathrin coat assembly protein AP180 isoform X7

UniProtKB/TrEMBL

Q3UI39

Conserved Domains (2) summary

PHA03247
Location:475 → 863

PHA03247; large tegument protein UL36; Provisional

pfam07651
Location:24 → 283

ANTH; ANTH domain