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    Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin [ Mus musculus (house mouse) ]

    Gene ID: 20612, updated on 5-Apr-2024

    Summary

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    Official Symbol
    Siglec1provided by MGI
    Official Full Name
    sialic acid binding Ig-like lectin 1, sialoadhesinprovided by MGI
    Primary source
    MGI:MGI:99668
    See related
    Ensembl:ENSMUSG00000027322 AllianceGenome:MGI:99668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sn; Cd169; Siglec-1
    Summary
    Predicted to enable virion binding activity. Acts upstream of or within positive regulation of T cell apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in early endosome; late endosome; and plasma membrane. Is expressed in immune system; reproductive system; and skin. Orthologous to human SIGLEC1 (sialic acid binding Ig like lectin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 31.7), spleen adult (RPKM 18.9) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Siglec1 in Genome Data Viewer
    Location:
    2 F1; 2 63.26 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130911140..130928697, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131067801..131086778, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microRNA 6973b Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 4 Neighboring gene a disintegrin and metallopeptidase domain 33 Neighboring gene STARR-seq mESC enhancer starr_05699 Neighboring gene predicted gene, 30378 Neighboring gene heat shock protein 12B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deleterious effect of bone marrow-resident macrophages on hematopoietic stem cells in response to total body irradiation. Chalot M, et al. Blood Adv, 2022 Mar 22. PMID 35100346, Free PMC Article
    2. CD169(+) lymph node macrophages have protective functions in mouse breast cancer metastasis. Tacconi C, et al. Cell Rep, 2021 Apr 13. PMID 33852863
    3. Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis. Singh R, et al. Elife, 2019 Dec 24. PMID 31872800, Free PMC Article
    4. Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1. Perez-Zsolt D, et al. Front Immunol, 2019. PMID 31114569, Free PMC Article
    5. Targeted Delivery of Antigen to Activated CD169(+) Macrophages Induces Bias for Expansion of CD8(+) T Cells. Edgar LJ, et al. Cell Chem Biol, 2019 Jan 17. PMID 30393066, Free PMC Article

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
      Title: CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
    2. CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis.
      Title: CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis.
    3. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
      Title: Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
    4. Campylobacter jejuni induces autoimmune peripheral neuropathy via Sialoadhesin and Interleukin-4 axes.
      Title: Campylobacter jejuni induces autoimmune peripheral neuropathy via Sialoadhesin and Interleukin-4 axes.
    5. Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.
      Title: Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.
    6. Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1.
      Title: Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1.
    7. the interaction between Siglec1-expressing SCS macrophages and pioneer metastatic cells drives cell cycle progression and enables efficient metastatic colonization
      Title: Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis.
    8. An IL-4R-dependent increase of CD169 was observed on pleural and bronchoalveolar macrophages in microfilaremic mice.
      Title: IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.
    9. the subset of peritoneal CD11b(+)CD169(+) macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis
      Title: Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22.
    10. A new subset of resident macrophages in the intestinal muscularis externa was discovered, identified as iba1(pos) CD169(neg).
      Title: Ionized calcium-binding adaptor molecule 1 positive macrophages and HO-1 up-regulation in intestinal muscularis resident macrophages.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (6) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis of virus by host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sialoadhesin
    Names
    SER
    sheep erythrocyte receptor
    sialic acid-binding Ig-like lectin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011426.3 → NP_035556.3  sialoadhesin precursor

      See identical proteins and their annotated locations for NP_035556.3

      Status: VALIDATED

      Source sequence(s)
      AA396073, BC141335, Z36293
      Consensus CDS
      CCDS16754.2
      UniProtKB/Swiss-Prot
      D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
      UniProtKB/TrEMBL
      G3X8X6
      Related
      ENSMUSP00000028794.4, ENSMUST00000028794.10
      Conserved Domains (9) summary
      cd05712
      Location:27 → 136
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00408
      Location:261 → 319
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:343 → 415
      IG; Immunoglobulin
      smart00410
      Location:624 → 702
      IG_like; Immunoglobulin like
      cd00096
      Location:1365 → 1440
      Ig; Immunoglobulin domain
      pfam08205
      Location:148 → 235
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:1269 → 1340
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:1090 → 1151
      Ig_3; Immunoglobulin domain
      cl11960
      Location:428 → 511
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130911140..130928697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499050.5 → XP_006499113.1  sialoadhesin isoform X3

      UniProtKB/Swiss-Prot
      D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
      Conserved Domains (9) summary
      cd05712
      Location:27 → 136
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00408
      Location:261 → 319
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:624 → 702
      IG; Immunoglobulin
      smart00410
      Location:343 → 415
      IG_like; Immunoglobulin like
      cd00096
      Location:1365 → 1440
      Ig; Immunoglobulin domain
      pfam08205
      Location:148 → 235
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:1269 → 1340
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:1090 → 1151
      Ig_3; Immunoglobulin domain
      cl11960
      Location:428 → 511
      Ig; Immunoglobulin domain

    2. XM_036159918.1 → XP_036015811.1  sialoadhesin isoform X2

      UniProtKB/Swiss-Prot
      D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
      Conserved Domains (9) summary
      smart00408
      Location:261 → 319
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:624 → 702
      IG; Immunoglobulin
      smart00410
      Location:1005 → 1093
      IG_like; Immunoglobulin like
      pfam08205
      Location:148 → 235
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:1095 → 1167
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:712 → 777
      Ig_3; Immunoglobulin domain
      cd00096
      Location:148 → 153
      Ig; Ig strand A [structural motif]
      cd05712
      Location:27 → 134
      IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
      cl11960
      Location:428 → 511
      Ig; Immunoglobulin domain

    3. XM_036159916.1 → XP_036015809.1  sialoadhesin isoform X1

      UniProtKB/Swiss-Prot
      D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
      Conserved Domains (9) summary
      smart00408
      Location:261 → 319
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:624 → 702
      IG; Immunoglobulin
      smart00410
      Location:1005 → 1093
      IG_like; Immunoglobulin like
      pfam08205
      Location:148 → 235
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:1095 → 1167
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:712 → 777
      Ig_3; Immunoglobulin domain
      cd00096
      Location:148 → 153
      Ig; Ig strand A [structural motif]
      cd05712
      Location:27 → 134
      IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
      cl11960
      Location:428 → 511
      Ig; Immunoglobulin domain

    4. XM_006499051.5 → XP_006499114.1  sialoadhesin isoform X4

      UniProtKB/Swiss-Prot
      D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
      Related
      ENSMUSP00000105856.2, ENSMUST00000110227.8
      Conserved Domains (9) summary
      cd05712
      Location:27 → 136
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00408
      Location:261 → 319
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:624 → 702
      IG; Immunoglobulin
      smart00410
      Location:343 → 415
      IG_like; Immunoglobulin like
      cd00096
      Location:1365 → 1440
      Ig; Immunoglobulin domain
      pfam08205
      Location:148 → 235
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:1269 → 1340
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:1090 → 1151
      Ig_3; Immunoglobulin domain
      cl11960
      Location:428 → 511
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62230.2 GenPept UniProtKB/Swiss-Prot:Q62230

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