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    Sstr5 somatostatin receptor 5 [ Mus musculus (house mouse) ]

    Gene ID: 20609, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Sstr5provided by MGI
    Official Full Name
    somatostatin receptor 5provided by MGI
    Primary source
    MGI:MGI:894282
    See related
    Ensembl:ENSMUSG00000050824 AllianceGenome:MGI:894282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sst5; Smstr5
    Summary
    Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Acts upstream of or within glucose homeostasis and regulation of insulin secretion. Located in plasma membrane. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to human SSTR5 (somatostatin receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 12.62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25708849..25716262, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25489875..25497288, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617 Neighboring gene STARR-seq mESC enhancer starr_42107 Neighboring gene tektin 4 Neighboring gene predicted gene, 53993 Neighboring gene predicted gene, 33727 Neighboring gene predicted gene, 33801

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Farb TB, et al. Endocrinology, 2017 Nov 1. PMID 28938487
    2. Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents. Córdoba-Chacón J, et al. Cell Mol Life Sci, 2010 Apr. PMID 20063038
    3. Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas. Patel SG, et al. World J Surg, 2009 Apr. PMID 19137362
    4. The effect of global SSTR5 gene ablation on the endocrine pancreas and glucose regulation in aging mice. Wang XP, et al. J Surg Res, 2005 Nov. PMID 16026801
    5. Deficiency of somatostatin (SST) receptor type 5 (SSTR5) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas. Ramírez JL, et al. Mol Cell Endocrinol, 2004 Jun 30. PMID 15223137

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
      Title: TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
    2. Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro.
      Title: Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro.
    3. Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
      Title: Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
    4. Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells.
      Title: Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells.
    5. rare enteroendocrine cell type in jejunum acts in a paracrine manner to regulate GLP-1 secretion through SSTR5
      Title: UTS2B Defines a Novel Enteroendocrine Cell Population and Regulates GLP-1 Secretion Through SSTR5 in Male Mice.
    6. The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
      Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
    7. mouse somatostatin receptor 5 is sorted by a network of PDZ-domain containing proteins
      Title: Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins.
    8. Findings suggest that somatostatin and its receptors (SSTR2 and SSTR5) are important markers in the regulation and development of Sertoli cell.
      Title: Somatostatin and its receptors: functional regulation in the development of mice Sertoli cells.
    9. In comparison to wt, ApoD(-/-) mice exhibit increased SSTR5-like immunoreactivity in paraventricular nuclei and decreased receptor expression in ventromedial hypothalamus and arcuate nucleus.
      Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.
    10. Somatostatin inhibited GIP and glucagon-like peptide-1 (GLP-1) secretion from primary small intestinal cultures, in part through SSTR5.
      Title: Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables somatostatin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables somatostatin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    somatostatin receptor type 5
    Names
    SS-5-R
    SS5-R
    SS5R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191008.1 → NP_001177937.1  somatostatin receptor type 5

      See identical proteins and their annotated locations for NP_001177937.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131323, AK133767
      Consensus CDS
      CCDS28520.1
      UniProtKB/Swiss-Prot
      A6H6N8, O08858, O08998, Q3UZM7
      UniProtKB/TrEMBL
      Q9JK40
      Related
      ENSMUSP00000128787.3, ENSMUST00000165183.11
      Conserved Domains (2) summary
      pfam00001
      Location:54 → 303
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48 → 227
      7tm_4; Olfactory receptor

    2. NM_011425.3 → NP_035555.1  somatostatin receptor type 5

      See identical proteins and their annotated locations for NP_035555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131323, AK133609
      Consensus CDS
      CCDS28520.1
      UniProtKB/Swiss-Prot
      A6H6N8, O08858, O08998, Q3UZM7
      UniProtKB/TrEMBL
      Q9JK40
      Related
      ENSMUSP00000051085.5, ENSMUST00000051864.6
      Conserved Domains (2) summary
      pfam00001
      Location:54 → 303
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48 → 227
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25708849..25716262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08858.3 GenPept UniProtKB/Swiss-Prot:O08858

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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