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    Sstr1 somatostatin receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 20605, updated on 21-Apr-2024

    Summary

    Official Symbol
    Sstr1provided by MGI
    Official Full Name
    somatostatin receptor 1provided by MGI
    Primary source
    MGI:MGI:98327
    See related
    Ensembl:ENSMUSG00000035431 AllianceGenome:MGI:98327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SS1R; sst1; SS1-R; SRIF-2; SS-1-R; Smstr1; Smstr-1
    Summary
    Enables somatostatin receptor activity. Acts upstream of or within cellular response to leukemia inhibitory factor; glutamate receptor signaling pathway; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; gut; and respiratory system. Orthologous to human SSTR1 (somatostatin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 12.3), CNS E18 (RPKM 7.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    12 C1; 12 25.61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (58258524..58262822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (58211421..58216037)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 6 Neighboring gene STARR-seq mESC enhancer starr_32227 Neighboring gene cDNA sequence BC042761 Neighboring gene STARR-seq mESC enhancer starr_32229 Neighboring gene predicted gene, 46329 Neighboring gene STARR-seq mESC enhancer starr_32231 Neighboring gene C-type lectin domain family 14, member a Neighboring gene predicted gene, 30687 Neighboring gene predicted gene, 40428

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables somatostatin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables somatostatin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables somatostatin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables somatostatin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    somatostatin receptor type 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411890.1NP_001398819.1  somatostatin receptor type 1

      Status: VALIDATED

      Source sequence(s)
      AC123932
      UniProtKB/Swiss-Prot
      P30873
      UniProtKB/TrEMBL
      Q543T0
    2. NM_009216.3NP_033242.1  somatostatin receptor type 1

      See identical proteins and their annotated locations for NP_033242.1

      Status: VALIDATED

      Source sequence(s)
      AC123932, AK046464
      Consensus CDS
      CCDS36456.1
      UniProtKB/Swiss-Prot
      P30873
      UniProtKB/TrEMBL
      Q543T0
      Related
      ENSMUSP00000106299.3, ENSMUST00000110671.3
      Conserved Domains (1) summary
      cd15970
      Location:59334
      7tmA_SSTR1; somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      58258524..58262822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)