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    Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20537, updated on 21-Apr-2024

    Summary

    Official Symbol
    Slc5a1provided by MGI
    Official Full Name
    solute carrier family 5 (sodium/glucose cotransporter), member 1provided by MGI
    Primary source
    MGI:MGI:107678
    See related
    Ensembl:ENSMUSG00000011034 AllianceGenome:MGI:107678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sglt1
    Summary
    Enables glucose transmembrane transporter activity. Involved in regulation of transporter activity. Acts upstream of or within glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane and brush border. Is expressed in alimentary system; brain; and urinary system. Orthologous to human SLC5A1 (solute carrier family 5 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 227.7), small intestine adult (RPKM 214.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    Location:
    5 B1; 5 17.46 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33261563..33320043)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33104219..33162699)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A, pseudogene 5 Neighboring gene predicted gene, 57738 Neighboring gene STARR-seq mESC enhancer starr_12816 Neighboring gene STARR-seq mESC enhancer starr_12817 Neighboring gene STARR-positive B cell enhancer ABC_E3567 Neighboring gene spondin 2, extracellular matrix protein Neighboring gene predicted gene, 54327

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-glucoside transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables galactose:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucose:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucose:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables water transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in alpha-glucoside transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal D-glucose absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intestinal absorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in renal glucose absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to inorganic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transepithelial water transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/glucose cotransporter 1
    Names
    Na(+)/glucose cotransporter 1
    high affinity sodium-glucose cotransporter
    solute carrier family 5, member 1
    solute carrier family 5, member alpha 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019810.4NP_062784.3  sodium/glucose cotransporter 1

      See identical proteins and their annotated locations for NP_062784.3

      Status: VALIDATED

      Source sequence(s)
      AC122203, AK033512, AK085602, BE688659
      Consensus CDS
      CCDS19199.1
      UniProtKB/TrEMBL
      Q8CCA7, Q9QXI6
      Related
      ENSMUSP00000011178.3, ENSMUST00000011178.5
      Conserved Domains (1) summary
      cl00456
      Location:27665
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      33261563..33320043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)