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    Slc4a3 solute carrier family 4 (anion exchanger), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 20536, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc4a3provided by MGI
    Official Full Name
    solute carrier family 4 (anion exchanger), member 3provided by MGI
    Primary source
    MGI:MGI:109350
    See related
    Ensembl:ENSMUSG00000006576 AllianceGenome:MGI:109350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ae3; A930038D23Rik
    Summary
    Enables anion:anion antiporter activity. Acts upstream of or within regulation of intracellular pH. Located in plasma membrane. Is expressed in dorsal root ganglion and nervous system. Orthologous to human SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 74.1), heart adult (RPKM 43.5) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc4a3 in Genome Data Viewer
    Location:
    1 C4; 1 39.16 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75522688..75536075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75546044..75559431)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5772 Neighboring gene STARR-positive B cell enhancer ABC_E5773 Neighboring gene STARR-positive B cell enhancer ABC_E4325 Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene predicted gene 15183 Neighboring gene STARR-positive B cell enhancer ABC_E4326 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01363 Neighboring gene STARR-seq mESC enhancer starr_01364 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA SEQ Analysis Indicates that the AE3 Cl(-)/HCO(3)(-) Exchanger Contributes to Active Transport-Mediated CO(2) Disposal in Heart. Vairamani K, et al. Sci Rep, 2017 Aug 4. PMID 28779178, Free PMC Article
    2. Role of Cl(-) -HCO(3)(-) exchanger AE3 in intracellular pH homeostasis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes. Salameh AI, et al. J Physiol, 2017 Jan 1. PMID 27353306, Free PMC Article
    3. The murine Cl⁻/HCO⁻₃ exchanger Ae3 (Slc4a3) is not required for acid-base balance but is involved in magnesium handling by the kidney. Kampik NB, et al. Cell Physiol Biochem, 2014. PMID 25402438
    4. Resistance to cardiomyocyte hypertrophy in ae3-/- mice, deficient in the AE3 Cl-/HCO3- exchanger. Sowah D, et al. BMC Cardiovasc Disord, 2014 Jul 21. PMID 25047106, Free PMC Article
    5. Loss of the AE3 Cl(-)/HCO(-) 3 exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart. Prasad V, et al. Front Physiol, 2013. PMID 24427143, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results support a model in which the AE3 Cl(-)/HCO3(-) exchanger, coupled with parallel Cl(-) and H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-mediated disposal of CO2.
      Title: RNA SEQ Analysis Indicates that the AE3 Cl(-)/HCO(3)(-) Exchanger Contributes to Active Transport-Mediated CO(2) Disposal in Heart.
    2. These findings suggest a new type of neuron-astrocyte communication, based on the expression of AE3 in neurons, which could explain how AE3 reduces seizure susceptibility
      Title: Role of Cl(-) -HCO(3)(-) exchanger AE3 in intracellular pH homeostasis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes.
    3. Ae3 is expressed in murine kidney at very low levels.
      Title: The murine Cl⁻/HCO⁻₃ exchanger Ae3 (Slc4a3) is not required for acid-base balance but is involved in magnesium handling by the kidney.
    4. Report the importance of AE3-mediated Cl-/HCO3- exchange in cardiovascular pH regulation and the development of cardiomyocyte hypertrophy.
      Title: Resistance to cardiomyocyte hypertrophy in ae3-/- mice, deficient in the AE3 Cl-/HCO3- exchanger.
    5. In the TM180 cardiomyopathy model, loss of AE3 had no apparent anti-hypertrophic effect and led to more rapid decompensation and heart failure.
      Title: Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.
    6. Identification of Slc4a3 as underlying a previously unrecognized cause of blindness suggests this gene as a new candidate for a subset of hereditary vitreoretinal retinal degeneration
      Title: Blindness caused by deficiency in AE3 chloride/bicarbonate exchanger.
    7. Association of AE3 and CAXIV may represent a mechanism to enhance disposal of waste CO(2) and to balance pH in excitable tissues.
      Title: Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction.
    8. It was concluded that the A867D allele is a functional mutant of AE3 and that the decreased activity of this mutation may cause changes in cell volume and abnormal intracellular pH.
      Title: Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3.
    9. In hippocampal neurons dissociated from anion exchanger AE3 knock-out mice, ammonium-induced alkalinization was much larger than that seen in neurons from wild-type mice.
      Title: Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons.
    10. AE3 and NKCC1 affect Ca2+ handling
      Title: Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bicarbonate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride:bicarbonate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride:bicarbonate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pH reduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of intracellular pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anion exchange protein 3
    Names
    AE 3
    anion exchanger 3
    neuronal band 3-like protein
    solute carrier family 4 member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357149.1 → NP_001344078.1  anion exchange protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115011
      Consensus CDS
      CCDS15080.1
      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:321 → 1226
      ae; anion exchange protein

    2. NM_001357150.1 → NP_001344079.1  anion exchange protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115011
      Consensus CDS
      CCDS15080.1
      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:321 → 1226
      ae; anion exchange protein

    3. NM_009208.3 → NP_033234.2  anion exchange protein 3

      See identical proteins and their annotated locations for NP_033234.2

      Status: VALIDATED

      Source sequence(s)
      AK147218, BC080271, BY276474
      Consensus CDS
      CCDS15080.1
      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Related
      ENSMUSP00000116747.2, ENSMUST00000124341.8
      Conserved Domains (1) summary
      TIGR00834
      Location:321 → 1226
      ae; anion exchange protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75522688..75536075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496450.4 → XP_006496513.1  anion exchange protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006496513.1

      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:321 → 1226
      ae; anion exchange protein

    2. XM_006496453.3 → XP_006496516.1  anion exchange protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006496516.1

      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:321 → 1226
      ae; anion exchange protein

    3. XM_036162945.1 → XP_036018838.1  anion exchange protein 3 isoform X2

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:251 → 1156
      ae; anion exchange protein

    4. XM_006496454.5 → XP_006496517.1  anion exchange protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006496517.1

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:251 → 1156
      ae; anion exchange protein

    5. XM_006496456.5 → XP_006496519.1  anion exchange protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006496519.1

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:251 → 1156
      ae; anion exchange protein

    6. XM_030252387.2 → XP_030108247.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1 → 736
      Band_3_cyto; Band 3 cytoplasmic domain

    7. XM_006496458.4 → XP_006496521.1  anion exchange protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006496521.1

      Conserved Domains (1) summary
      cl26877
      Location:1 → 736
      Band_3_cyto; Band 3 cytoplasmic domain

    8. XM_006496455.4 → XP_006496518.1  anion exchange protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006496518.1

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:251 → 1156
      ae; anion exchange protein

    9. XM_036162961.1 → XP_036018854.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1 → 736
      Band_3_cyto; Band 3 cytoplasmic domain

    10. XM_030252388.2 → XP_030108248.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1 → 736
      Band_3_cyto; Band 3 cytoplasmic domain

    11. XM_006496451.4 → XP_006496514.1  anion exchange protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006496514.1

      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:321 → 1226
      ae; anion exchange protein

    12. XM_006496457.1 → XP_006496520.1  anion exchange protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006496520.1

      UniProtKB/TrEMBL
      Q9ERP4
      Conserved Domains (1) summary
      TIGR00834
      Location:124 → 1029
      ae; anion exchange protein

    13. XM_036162963.1 → XP_036018856.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1 → 736
      Band_3_cyto; Band 3 cytoplasmic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16283.2 GenPept UniProtKB/Swiss-Prot:P16283

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