Slc4a1ap solute carrier family 4 (anion exchanger), member 1, adaptor protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc4a1approvided by MGI
Official Full Name: solute carrier family 4 (anion exchanger), member 1, adaptor proteinprovided by MGI
Primary source: MGI:MGI:1196608
See related: Ensembl:ENSMUSG00000029141 AllianceGenome:MGI:1196608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: kanadaptin
Summary: Predicted to enable mRNA binding activity. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SLC4A1AP (solute carrier family 4 member 1 adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 4.3), CNS E14 (RPKM 3.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.27 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31684125..31711386)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31526781..31561755)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kanadaptin

Names: solute carrier family 4 (anion exchanger), member 1, adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347328.1 → NP_001334257.1 kanadaptin isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC113276, AC114613

Consensus CDS

CCDS84865.1

UniProtKB/TrEMBL

E9PX68

Related

ENSMUSP00000144257.2, ENSMUST00000202950.4
NM_001359154.1 → NP_001346083.1 kanadaptin isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC113276, AC114613

Conserved Domains (2) summary

cd00060
Location:113 → 221

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00035
Location:316 → 384

dsrm; Double-stranded RNA binding motif
NM_001359156.1 → NP_001346085.1 kanadaptin isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC113276, AC114613

UniProtKB/TrEMBL

Q3UUI2

Conserved Domains (2) summary

cd00060
Location:113 → 221

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00035
Location:316 → 384

dsrm; Double-stranded RNA binding motif
NM_001359157.1 → NP_001346086.1 kanadaptin isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the C-terminus compared to isoform 1.

Source sequence(s)

AC113276, BC072588

Consensus CDS

CCDS89902.1

UniProtKB/TrEMBL

E9Q1Q0, Q6GQW1

Related

ENSMUSP00000143960.2, ENSMUST00000201858.4

Conserved Domains (2) summary

cd00060
Location:113 → 221

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00035
Location:316 → 384

dsrm; Double-stranded RNA binding motif
NM_001421405.1 → NP_001408334.1 kanadaptin isoform 6

Status: VALIDATED

Source sequence(s)

AC113276, AC114613
NM_001421406.1 → NP_001408335.1 kanadaptin isoform 7

Status: VALIDATED

Source sequence(s)

AC113276, AC114613
NM_009206.2 → NP_033232.2 kanadaptin isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK138398, AK149108, BC090964

Consensus CDS

CCDS51460.1

UniProtKB/TrEMBL

E9Q585

Related

ENSMUSP00000110179.3, ENSMUST00000114533.9

Conserved Domains (4) summary

COG1716
Location:110 → 245

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:113 → 221

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00035
Location:316 → 384

dsrm; Double-stranded RNA binding motif

pfam04895
Location:432 → 485

DUF651; Archaeal protein of unknown function (DUF651)