Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a3provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 3provided by MGI
Primary source: MGI:MGI:95757
See related: Ensembl:ENSMUSG00000003153 AllianceGenome:MGI:95757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glut3; Glut-3
Summary: Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Located in acrosomal membrane and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; early conceptus; and reproductive system. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 213.3), placenta adult (RPKM 31.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F2; 6 57.82 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (122704783..122779149, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (122727809..122802363, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
Title: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
Title: Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Title: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
Title: Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
Title: Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
Title: Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
Title: High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
Title: CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
Title: Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer's Disease Model Mice.
Title: Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer's Disease Model Mice.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:547073

NoName (e-PCR)
- UniSTS:235551

NoName (e-PCR)
- UniSTS:235552

RH124751 (e-PCR)
- UniSTS:161573

RH125444 (e-PCR)
- UniSTS:161573

RH125527 (e-PCR)
- UniSTS:162343

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:144424

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:144425

UniSTS:144426 (e-PCR)
- UniSTS:144426

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:144426

PMC20520P1 (e-PCR)
- UniSTS:271942

AU040424 (e-PCR)
- UniSTS:159568

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:516694

D19270 (e-PCR)
- UniSTS:124798

U11853 (e-PCR)
- UniSTS:125668

RH126356 (e-PCR)
- UniSTS:163064

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables galactose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables galactoside binding	ISO Inferred from Sequence Orthology more info
enables glucose binding	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables monosaccharide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xylose binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose import	ISO Inferred from Sequence Orthology more info
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monosaccharide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 3

Names: glucose transporter type 3, brain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410371.1 → NP_001397300.1 solute carrier family 2, facilitated glucose transporter member 3 isoform c

Status: VALIDATED

Source sequence(s)

AC131715
NM_001410372.1 → NP_001397301.1 solute carrier family 2, facilitated glucose transporter member 3 isoform d

Status: VALIDATED

Source sequence(s)

AC131715, AC163108
NM_001410374.1 → NP_001397303.1 solute carrier family 2, facilitated glucose transporter member 3 isoform d

Status: VALIDATED

Source sequence(s)

AC131715, AC163108
NM_001410375.1 → NP_001397304.1 solute carrier family 2, facilitated glucose transporter member 3 isoform a

Status: VALIDATED

Source sequence(s)

AC131715, AC163108
NM_001410376.1 → NP_001397305.1 solute carrier family 2, facilitated glucose transporter member 3 isoform a

Status: VALIDATED

Source sequence(s)

AC131715, AC163108
NM_001410377.1 → NP_001397306.1 solute carrier family 2, facilitated glucose transporter member 3 isoform a

Status: VALIDATED

Source sequence(s)

AC131715, AC163108
NM_001410378.1 → NP_001397307.1 solute carrier family 2, facilitated glucose transporter member 3 isoform a

Status: VALIDATED

Source sequence(s)

AC131715, AC163108
NM_011401.5 → NP_035531.3 solute carrier family 2, facilitated glucose transporter member 3 isoform b

See identical proteins and their annotated locations for NP_035531.3

Status: VALIDATED

Source sequence(s)

AC131715

Consensus CDS

CCDS20502.1

UniProtKB/Swiss-Prot

P32037

UniProtKB/TrEMBL

Q3TPL8, Q4FJP8, Q8BLF7

Related

ENSMUSP00000032476.5, ENSMUST00000032476.11

Conserved Domains (2) summary

cd06174
Location:14 → 437

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:13 → 465

Sugar_tr; Sugar (and other) transporter

RNA

NR_177063.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC131715

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

122704783..122779149 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165983.1 → XP_036021876.1 solute carrier family 2, facilitated glucose transporter member 3 isoform X1

UniProtKB/TrEMBL

Q4FJP8, Q8BLF7

Conserved Domains (1) summary

cd17431
Location:14 → 458

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily