Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a12provided by MGI
Official Full Name: solute carrier family 22 (organic anion/cation transporter), member 12provided by MGI
Primary source: MGI:MGI:1195269
See related: Ensembl:ENSMUSG00000061742 AllianceGenome:MGI:1195269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rst; OAT4L; URAT1; Slc22al2
Summary: Enables urate transmembrane transporter activity. Acts upstream of or within urate transport. Located in brush border membrane. Is integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; male reproductive gland or organ; metanephros; and retina layer. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 561.9) See more
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Genomic context

Location:: 19 A; 19 5.05 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6585884..6593100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6535854..6543070, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice.
Title: URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice.
Extracellular uric acid levels in the proximal tubule epithelial cells positively regulated URAT1 expression.Renal URAT1 expression increased in hyperuricemic mice.
Title: Urate Transporter URAT1 in Hyperuricemia: New Insights from Hyperuricemic Models.
Urat1-Uox double knockout mice are a suitable animal model for renal hypouricemia.
Title: Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury.
Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1, ABCG2, and URAT1. Immunostaining for GLUT9 was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.
Title: Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain.
The cause of obesity/metabolic syndrome-associated hyperuricemia appears to be associated with the urate reabsorption transporter Urat1 protein enhanced by fat.
Title: The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice.
Although the fractional excretion of urate of knockout mice was tend to higher than that of wildtype mice, the urate reabsorption ability remained in the kidney of knockout mice, indicating a urate reabsorptive transporter other than Urat1.
Title: Establishment and analysis of SLC22A12 (URAT1) knockout mouse.
NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the brush Border membrane abundance of mURAT1.
Title: Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport.
mouse RST mediates the efflux of organic anions including urate and works as exit for organic anions in the proximal tubules
Title: The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Slc22a12 (e-PCR), detects polymorphism
- UniSTS:463368

Slc22a12 (e-PCR), detects polymorphism
- UniSTS:496051

AI987855 (e-PCR)
- UniSTS:166114

Slc22a12 (e-PCR), detects polymorphism
- UniSTS:547318

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables urate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in urate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 22 member 12

Names: renal-specific transporter; solute carrier family 22 (organic cation transporter)-like 2; urate anion exchanger 1; urate:anion antiporter SLC22A12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009203.3 → NP_033229.3 solute carrier family 22 member 12

See identical proteins and their annotated locations for NP_033229.3

Status: VALIDATED

Source sequence(s)

AB005451, AI314749, AK142580, BX631781, CD241755

Consensus CDS

CCDS29505.1

UniProtKB/Swiss-Prot

O54778, Q8CFZ5

UniProtKB/TrEMBL

A0A0R4J1I9

Related

ENSMUSP00000109078.2, ENSMUST00000113451.9

Conserved Domains (2) summary

cd06174
Location:147 → 516

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 526

2A0119; cation transport protein