Slc17a1 solute carrier family 17 (sodium phosphate), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc17a1provided by MGI
Official Full Name: solute carrier family 17 (sodium phosphate), member 1provided by MGI
Primary source: MGI:MGI:103209
See related: Ensembl:ENSMUSG00000021335 AllianceGenome:MGI:103209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Npt1; Napi1; NAPI-1
Summary: Predicted to enable sialic acid transmembrane transporter activity. Predicted to be involved in sialic acid transport; urate metabolic process; and urate transport. Predicted to act upstream of or within sodium ion transport. Predicted to be located in apical plasma membrane. Predicted to be active in lysosome. Predicted to be integral component of plasma membrane. Is expressed in cortical renal tubule and lower jaw molar. Orthologous to human SLC17A1 (solute carrier family 17 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 67.9) See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 9.97 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (24051607..24079713)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (23867624..23895730)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions
Title: Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter.
Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
Title: Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
The finding of VGLUT1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles may reflect differences in functional properties and the embryonic origin between skeletal and esophageal striated muscle fibers.
Title: Vesicular glutamate transporter 1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles in the mouse.
Mossy terminals are immunoreactive for VGLUT1 and mGluR1alpha dendritic brushes are immunopositive for VGLUT1 in organotypic cultures of mouse vestibulocerebellum.
Title: Vesicular glutamate transporters VGLUT1 and VGLUT2 define two subsets of unipolar brush cells in organotypic cultures of mouse vestibulocerebellum.
Data show that hepatocyte nuclear factor 1 alpha (HNF1alpha) directly transactivates the Npt1 promoter and that the HSS3 region contributes to this activation.
Title: Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc17a1 (e-PCR), detects polymorphism
- UniSTS:547005

NoName (e-PCR)
- UniSTS:224227

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in monoatomic anion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in urate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium-dependent phosphate transport protein 1

Names: Na(+)/PI cotransporter 1; renal Na(+)-dependent phosphate cotransporter 1; renal sodium-phosphate transport protein 1; sodium-dependent phosphate/anion cotransporter; sodium/phosphate type I cotransporter; solute carrier family 17 (sodium/hydrogen exchanger), member 1; solute carrier family 17 vesicular glutamate transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170638.1 → NP_001164109.1 sodium-dependent phosphate transport protein 1

See identical proteins and their annotated locations for NP_001164109.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AA986929, AI663290, AK132800, AK164712, AW261800, CJ065843

Consensus CDS

CCDS26372.1

UniProtKB/Swiss-Prot

A9Z1Z4, Q61983, Q91YA1

UniProtKB/TrEMBL

Q91WV5

Related

ENSMUSP00000106043.2, ENSMUST00000110413.8

Conserved Domains (2) summary

cd06174
Location:71 → 449

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:1 → 464

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
NM_009198.3 → NP_033224.3 sodium-dependent phosphate transport protein 1

See identical proteins and their annotated locations for NP_033224.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the protein. Variants 1 and 2 encode the same protein.

Source sequence(s)

AA986929, AI116499, AI663290, AK132800, AK164712, AW261800, CJ065843

Consensus CDS

CCDS26372.1

UniProtKB/Swiss-Prot

A9Z1Z4, Q61983, Q91YA1

UniProtKB/TrEMBL

Q91WV5

Related

ENSMUSP00000006785.8, ENSMUST00000006785.8

Conserved Domains (2) summary

cd06174
Location:71 → 449

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:1 → 464

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RNA

NR_121611.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI663290, AK132800, AK164712, AL590388, AL606464

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

24051607..24079713

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516616.4 → XP_006516679.1 sodium-dependent phosphate transport protein 1 isoform X1

UniProtKB/TrEMBL

Q91WV5

Conserved Domains (1) summary

TIGR00894
Location:34 → 497

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
XM_006516617.2 → XP_006516680.1 sodium-dependent phosphate transport protein 1 isoform X2

UniProtKB/TrEMBL

Q91WV5

Conserved Domains (1) summary

TIGR00894
Location:1 → 376

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter