Sin3b transcriptional regulator, SIN3B (yeast) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sin3bprovided by MGI
Official Full Name: transcriptional regulator, SIN3B (yeast)provided by MGI
Primary source: MGI:MGI:107158
See related: Ensembl:ENSMUSG00000031622 AllianceGenome:MGI:107158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810430C10Rik
Summary: Enables chromatin binding activity and transcription corepressor activity. Involved in cardiac muscle tissue development; negative regulation of transcription, DNA-templated; and skeletal muscle tissue development. Located in several cellular components, including autosome; nucleus; and sex chromosome. Is expressed in several structures, including central nervous system; dorsal root ganglion; eye; genitourinary system; and paraxial mesenchyme. Orthologous to human SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 76.5), genital fat pad adult (RPKM 49.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 35.08 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (73449898..73484831)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (72723270..72758203)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells.
Title: Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells.
Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Title: Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Active compounds showed a new chemo-type for inhibitors of the REST/NRSF-mSin3 interaction, raising the possibility of new therapies for neuropathies caused by dysregulation of REST/NRSF.
Title: Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities.
this study shows that negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39
Title: Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39.
Low SIN3B expression is associated with Prostate Cancer Progression.
Title: Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence.
these results identify Sin3B as a novel and critical regulator of hematopoietic stem cells functions.
Title: The chromatin-associated Sin3B protein is required for hematopoietic stem cell functions in mice.
adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Title: The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes.
Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion.
Title: Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation.
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
Title: Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression.
interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.
Title: Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit194 (e-PCR), detects polymorphism
- UniSTS:131401

Sin3b (e-PCR), detects polymorphism
- UniSTS:472921

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in X chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in XY body	IDA Inferred from Direct Assay more info	PubMed
located_in Y chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in autosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: paired amphipathic helix protein Sin3b

Names: SIN3 homolog B, transcription regulator; histone deacetylase complex subunit Sin3b; transcriptional corepressor Sin3b; transcriptional regulator, SIN3 yeast homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113248.2 → NP_001106719.1 paired amphipathic helix protein Sin3b isoform 2

See identical proteins and their annotated locations for NP_001106719.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC171917, AK169433, BF318403

Consensus CDS

CCDS52598.1

UniProtKB/TrEMBL

Q3TN09

Related

ENSMUSP00000105576.4, ENSMUST00000109950.5

Conserved Domains (1) summary

pfam02671
Location:53 → 97

PAH; Paired amphipathic helix repeat
NM_009188.4 → NP_033214.2 paired amphipathic helix protein Sin3b isoform 1

See identical proteins and their annotated locations for NP_033214.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).

Source sequence(s)

AC171917, AK169433

Consensus CDS

CCDS52599.1

UniProtKB/Swiss-Prot

O54976, Q62141, Q6A013, Q8VCB8, Q8VDZ5

UniProtKB/TrEMBL

Q3TXW9

Related

ENSMUSP00000004494.9, ENSMUST00000004494.16

Conserved Domains (3) summary

pfam02671
Location:53 → 97

PAH; Paired amphipathic helix repeat

pfam08295
Location:386 → 480

Sin3_corepress; Sin3 family co-repressor

pfam16879
Location:712 → 1011

Sin3a_C; C-terminal domain of Sin3a protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

73449898..73484831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530789.2 → XP_006530852.1 paired amphipathic helix protein Sin3b isoform X1

UniProtKB/TrEMBL

Q3TXW9

Conserved Domains (1) summary

COG5602
Location:40 → 1030

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]