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    St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20442, updated on 21-Apr-2024

    Summary

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    Official Symbol
    St3gal1provided by MGI
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by MGI
    Primary source
    MGI:MGI:98304
    See related
    Ensembl:ENSMUSG00000013846 AllianceGenome:MGI:98304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat4; Siat4a; ST3GalI; St3gal-1; 5330418N22Rik
    Summary
    Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in several processes, including ganglioside biosynthetic process via lactosylceramide; memory B cell differentiation; and negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process. Acts upstream of or within protein glycosylation and protein phosphorylation. Predicted to be located in Golgi medial cisterna membrane; Golgi trans cisterna membrane; and trans-Golgi network membrane. Is expressed in several structures, including alimentary system; ear; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 22.6), liver adult (RPKM 19.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D2; 15 29.3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66974724..67048575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (67102875..67176946, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38892 Neighboring gene STARR-seq mESC enhancer starr_38895 Neighboring gene STARR-seq mESC enhancer starr_38896 Neighboring gene predicted gene, 31286 Neighboring gene predicted gene, 31342 Neighboring gene STARR-positive B cell enhancer ABC_E7376 Neighboring gene STARR-positive B cell enhancer ABC_E5486 Neighboring gene STARR-positive B cell enhancer ABC_E1907 Neighboring gene STARR-positive B cell enhancer ABC_E4135 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:67041844-67042027 Neighboring gene RIKEN cDNA 1700012I11 gene Neighboring gene predicted gene, 31400 Neighboring gene STARR-seq mESC enhancer starr_38899 Neighboring gene STARR-seq mESC enhancer starr_38900 Neighboring gene STARR-seq mESC enhancer starr_38902 Neighboring gene STARR-seq mESC enhancer starr_38903 Neighboring gene predicted gene, 53906

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma. Bai Q, et al. BMC Cancer, 2015 Nov 9. PMID 26552809, Free PMC Article
    2. Mutational analysis for enzyme activity of mouse Galbeta1,3GalNAc alpha2,3-sialyltransferase (mST3Gal I). Kim KS, et al. Indian J Biochem Biophys, 2010 Jun. PMID 20653283
    3. The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development. Kao C, et al. J Immunol, 2006 Jun 15. PMID 16751387
    4. Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. Grabie N, et al. Eur J Immunol, 2002 Oct. PMID 12355428
    5. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Priatel JJ, et al. Immunity, 2000 Mar. PMID 10755614

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ST3GAL-1 is an independent adverse prognostic factor for recurrence and survival of patients with clear cell renal cell carcinoma
      Title: Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma.
    2. tryptophan and cysteine residues conserved in ST3Gal I are critical for its activity
      Title: Mutational analysis for enzyme activity of mouse Galbeta1,3GalNAc alpha2,3-sialyltransferase (mST3Gal I).
    3. St3gal-1 functions to protect CD8 T cells from apoptosis
      Title: The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis.
    4. tissue-specific alterations in sialylation and sialic acid 9-O-acetylation in knockout mice
      Title: Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
    5. was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
      Title: Sialyltransferase specificity in selectin ligand formation.
    6. ST3Gal-I mRNA is extensively expressed during Th2, but not Th1 differentiation; suggests that lack of ST3Gal-I expression in Th1 cells allows the formation of surface core2 O-glycans and supports their interactions with endothelial selectins
      Title: Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins.
    7. STsGal-I deficiency shows no discernible effect on the pattern of CD8 noncognate binding during thymocyte development and does not impact susceptibility of thymocytes to CD8-induced apoptosis.
      Title: The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90735

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process via lactosylceramide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in memory B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sialylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi medial cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi trans cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
    Names
    CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
    Gal beta1,3 GalNAc alpha2,3 sialyltransferase
    SIAT4-A
    ST3GAL-I sialyltransferase
    ST3Gal I
    ST3GalA.1
    ST3O
    alpha 2,3-ST 1
    beta-galactoside alpha-2,3-sialyltransferase 1
    gal-NAc6S
    gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    monosialoganglioside sialyltransferase
    sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
    sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
    NP_001399564.1
    NP_001399565.1
    NP_001399566.1
    NP_033203.1
    XP_006520727.1
    XP_036015180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412635.1 → NP_001399564.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC087116, AC166984
      UniProtKB/Swiss-Prot
      P54751, Q11202
      UniProtKB/TrEMBL
      Q544T4

    2. NM_001412636.1 → NP_001399565.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC087116, AC166984
      UniProtKB/Swiss-Prot
      P54751, Q11202
      UniProtKB/TrEMBL
      Q544T4
      Related
      ENSMUSP00000155359.2, ENSMUST00000229213.2

    3. NM_001412637.1 → NP_001399566.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC087116, AC166984
      UniProtKB/Swiss-Prot
      P54751, Q11202
      UniProtKB/TrEMBL
      Q544T4
      Related
      ENSMUSP00000090307.6, ENSMUST00000092640.6

    4. NM_009177.5 → NP_033203.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

      See identical proteins and their annotated locations for NP_033203.1

      Status: VALIDATED

      Source sequence(s)
      AC087116, AC166984
      Consensus CDS
      CCDS27511.1
      UniProtKB/Swiss-Prot
      P54751, Q11202
      UniProtKB/TrEMBL
      Q3UU61, Q544T4
      Related
      ENSMUSP00000154853.2, ENSMUST00000229028.2
      Conserved Domains (1) summary
      pfam00777
      Location:80 → 335
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      66974724..67048575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520664.5 → XP_006520727.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006520727.1

      UniProtKB/Swiss-Prot
      P54751, Q11202
      UniProtKB/TrEMBL
      Q3UU61, Q544T4
      Conserved Domains (1) summary
      pfam00777
      Location:80 → 335
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_036159287.1 → XP_036015180.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      P54751, Q11202
      UniProtKB/TrEMBL
      Q3UU61, Q544T4
      Conserved Domains (1) summary
      pfam00777
      Location:80 → 335
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033487.1: Suppressed sequence

      Description
      NM_001033487.1: This RefSeq was permanently suppressed because it was primarily intronic sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54751.1 GenPept UniProtKB/Swiss-Prot:P54751

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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