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    St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 20441, updated on 11-Apr-2024

    Summary

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    Official Symbol
    St3gal3provided by MGI
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by MGI
    Primary source
    MGI:MGI:1316659
    See related
    Ensembl:ENSMUSG00000028538 AllianceGenome:MGI:1316659
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ST3N; Siat3; Siat6; ST3GalIII
    Summary
    Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; eye; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 43.9), adrenal adult (RPKM 31.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1- D2.1; 4 53.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117789349..117992169, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117932152..118134972, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10251 Neighboring gene importin 13 Neighboring gene artemin Neighboring gene RIKEN cDNA 9530034E10 gene Neighboring gene predicted gene, 54253 Neighboring gene STARR-seq mESC enhancer starr_11191 Neighboring gene STARR-seq mESC enhancer starr_11192 Neighboring gene STARR-positive B cell enhancer ABC_E6201 Neighboring gene lysine (K)-specific demethylase 4A Neighboring gene predicted gene, 23382 Neighboring gene predicted gene, 54252

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation. Rivero O, et al. Front Genet, 2021. PMID 34650588, Free PMC Article
    2. Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. Kiwamoto T, et al. J Allergy Clin Immunol, 2014 Jan. PMID 23830412, Free PMC Article
    3. Developmental patterns of GalBeta1,3(4)GlcNAc alpha2,3-sialyltransferase (ST3Gal III) expression in the mouse: in situ hybridization using DIG-labeled RNA probes. Ji MY, et al. Arch Pharm Res, 1999 Jun. PMID 10403125
    4. Sialylation regulates brain structure and function. Yoo SW, et al. FASEB J, 2015 Jul. PMID 25846372, Free PMC Article
    5. Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a. Teruel R, et al. J Biomed Sci, 2013 May 16. PMID 23678987, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
      Title: Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
    2. St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.
      Title: Sialylation regulates brain structure and function.
    3. knock-out mice have enhanced allergic eosinophilic airway inflammation
      Title: Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation.
    4. mRNA levels of St3gal3 potentially involved in antithrombin sialylation, were 85% lower in neonates in comparison with adults.
      Title: Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a.
    5. these studies demonstrate that ST3Gal-III plays an important role in Siglec-F ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung.
      Title: Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.
    6. was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
      Title: Sialyltransferase specificity in selectin ligand formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process via lactosylceramide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
    Names
    N-acetyllactosaminide alpha-2,3-sialyltransferase
    alpha 2,3-ST 3
    beta-galactoside alpha-2,3-sialyltransferase 3
    gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase
    sialyltransferase 3
    sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
    NP_001155246.1
    NP_001272449.1
    NP_001272450.1
    NP_033202.3
    XP_006502953.1
    XP_006502954.1
    XP_006502955.1
    XP_006502956.1
    XP_006502957.1
    XP_006502958.1
    XP_006502959.1
    XP_006502960.1
    XP_006502961.1
    XP_006502962.1
    XP_030109232.1
    XP_030109233.1
    XP_030109234.1
    XP_030109235.1
    XP_036019823.1
    XP_036019824.1
    XP_036019825.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161774.2 → NP_001155246.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

      See identical proteins and their annotated locations for NP_001155246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
      Source sequence(s)
      AK013016, BB868500, BF472945, CX240214
      Consensus CDS
      CCDS18544.1
      UniProtKB/Swiss-Prot
      P97325, Q922X5
      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Related
      ENSMUSP00000102018.2, ENSMUST00000106410.8
      Conserved Domains (1) summary
      pfam00777
      Location:106 → 370
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001285520.1 → NP_001272449.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

      See identical proteins and their annotated locations for NP_001272449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
      Source sequence(s)
      AK005053, AK136442, BB868500, BF472945
      Consensus CDS
      CCDS18544.1
      UniProtKB/Swiss-Prot
      P97325, Q922X5
      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:106 → 370
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_001285521.1 → NP_001272450.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform b

      See identical proteins and their annotated locations for NP_001272450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK013016, BB868500, BF472945
      Consensus CDS
      CCDS71458.1
      UniProtKB/TrEMBL
      Q3UWD5, Q9CZ48, Q9DBB6
      Related
      ENSMUSP00000095525.2, ENSMUST00000097912.8
      Conserved Domains (1) summary
      pfam00777
      Location:90 → 354
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_009176.5 → NP_033202.3  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

      See identical proteins and their annotated locations for NP_033202.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode isoform a.
      Source sequence(s)
      AK005053, AK136442, AL611952, BB868500, BF472945
      Consensus CDS
      CCDS18544.1
      UniProtKB/Swiss-Prot
      P97325, Q922X5
      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Related
      ENSMUSP00000030263.3, ENSMUST00000030263.9
      Conserved Domains (1) summary
      pfam00777
      Location:106 → 370
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      117789349..117992169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502898.4 → XP_006502961.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

      See identical proteins and their annotated locations for XP_006502961.1

      UniProtKB/TrEMBL
      Q3UWD5, Q9CZ48, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:90 → 354
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006502895.1 → XP_006502958.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

      See identical proteins and their annotated locations for XP_006502958.1

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:106 → 398
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_036163930.1 → XP_036019823.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:128 → 392
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_036163931.1 → XP_036019824.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

      UniProtKB/TrEMBL
      Q3UWD5, Q9CZ48, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:90 → 354
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_030253375.1 → XP_030109235.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X6

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:112 → 376
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_030253374.2 → XP_030109234.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:90 → 382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_006502892.3 → XP_006502955.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006502955.1

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:128 → 420
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. XM_006502894.2 → XP_006502957.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

      See identical proteins and their annotated locations for XP_006502957.1

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:106 → 398
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    9. XM_030253373.1 → XP_030109233.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:90 → 382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    10. XM_030253372.1 → XP_030109232.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:106 → 398
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    11. XM_006502891.3 → XP_006502954.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006502954.1

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:128 → 420
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    12. XM_006502897.3 → XP_006502960.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:90 → 382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    13. XM_006502893.3 → XP_006502956.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X2

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:112 → 404
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    14. XM_006502896.3 → XP_006502959.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:128 → 392
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    15. XM_006502890.3 → XP_006502953.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006502953.1

      UniProtKB/TrEMBL
      Q3UWD5, Q9DBB6
      Conserved Domains (1) summary
      pfam00777
      Location:128 → 420
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    16. XM_036163932.1 → XP_036019825.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X9

      Conserved Domains (1) summary
      pfam00777
      Location:128 → 276
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    17. XM_006502899.3 → XP_006502962.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X8

      Conserved Domains (1) summary
      pfam00777
      Location:128 → 271
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. XR_004941855.1 RNA Sequence

    2. XR_376302.4 RNA Sequence

    3. XR_376301.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97325.2 GenPept UniProtKB/Swiss-Prot:P97325

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