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    Shd src homology 2 domain-containing transforming protein D [ Mus musculus (house mouse) ]

    Gene ID: 20420, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Shdprovided by MGI
    Official Full Name
    src homology 2 domain-containing transforming protein Dprovided by MGI
    Primary source
    MGI:MGI:1099461
    See related
    Ensembl:ENSMUSG00000039154 AllianceGenome:MGI:1099461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Orthologous to human SHD (Src homology 2 domain containing transforming protein D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 43.7), CNS E14 (RPKM 40.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 D; 17 29.09 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56276828..56283624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55969828..55976620)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 119b Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene predicted gene, 16712 Neighboring gene Epstein-Barr virus induced gene 3 Neighboring gene YJU2 splicing factor Neighboring gene fibronectin type 3 and SPRY domain-containing protein Neighboring gene signal transducing adaptor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2497

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Ritter N, et al. Dev Cell, 2019 Sep 9. PMID 31422919
    2. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oda T, et al. Oncogene, 1997 Sep. PMID 9315092
    3. Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Chern T, et al. Nat Commun, 2022 Jan 10. PMID 35013307, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118480

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159523.2 → NP_001152995.1  SH2 domain-containing adapter protein D isoform 1

      See identical proteins and their annotated locations for NP_001152995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154235, CT009719
      Consensus CDS
      CCDS50149.1
      UniProtKB/Swiss-Prot
      O88834
      Related
      ENSMUSP00000153605.2, ENSMUST00000223629.2
      Conserved Domains (1) summary
      cd10390
      Location:224 → 321
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

    2. NM_001410665.1 → NP_001397594.1  SH2 domain-containing adapter protein D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    3. NM_001410666.1 → NP_001397595.1  SH2 domain-containing adapter protein D isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    4. NM_001410667.1 → NP_001397596.1  SH2 domain-containing adapter protein D isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    5. NM_001410668.1 → NP_001397597.1  SH2 domain-containing adapter protein D isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    6. NM_001410669.1 → NP_001397598.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    7. NM_001410670.1 → NP_001397599.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    8. NM_001410671.1 → NP_001397600.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    9. NM_001410672.1 → NP_001397601.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    10. NM_001410673.1 → NP_001397602.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    11. NM_009168.3 → NP_033194.1  SH2 domain-containing adapter protein D isoform 2

      See identical proteins and their annotated locations for NP_033194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC154235, CT009719
      Consensus CDS
      CCDS89120.1
      UniProtKB/Swiss-Prot
      O88834, Q3SYI7
      Related
      ENSMUSP00000047656.8, ENSMUST00000044216.8
      Conserved Domains (1) summary
      cd10390
      Location:223 → 320
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

    RNA

    1. NR_177106.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56276828..56283624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249612.1 → XP_030105472.1  SH2 domain-containing adapter protein D isoform X2

      UniProtKB/Swiss-Prot
      O88834, Q3SYI7
      Conserved Domains (1) summary
      cd10390
      Location:223 → 320
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

    2. XM_011246334.4 → XP_011244636.1  SH2 domain-containing adapter protein D isoform X1

      See identical proteins and their annotated locations for XP_011244636.1

      UniProtKB/Swiss-Prot
      O88834
      Conserved Domains (1) summary
      cd10390
      Location:224 → 321
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88834.1 GenPept UniProtKB/Swiss-Prot:O88834

    Gene LinkOut

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