Shbg sex hormone binding globulin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shbgprovided by MGI
Official Full Name: sex hormone binding globulinprovided by MGI
Primary source: MGI:MGI:98295
See related: Ensembl:ENSMUSG00000005202 AllianceGenome:MGI:98295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ABP
Summary: Predicted to enable steroid binding activity. Predicted to be involved in primary spermatocyte growth. Predicted to be located in extracellular region. Is expressed in testis. Human ortholog(s) of this gene implicated in endometrial cancer and type 2 diabetes mellitus. Orthologous to human SHBG (sex hormone binding globulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 8.7), liver E14 (RPKM 8.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.86 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69501108..69508852, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69610282..69618026, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.
Title: Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.
SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome
Title: Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages.
monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha levels, which in turn attenuated SHBG expression.
Title: Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene.
USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter
Title: Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors.
A wave of apoptosis during the pre-pubertal period is required for normal spermatogenesis to develop, and our data indicate that this apoptotic wave may be regulated by ABP and/or androgens.
Title: Dynamics of testicular germ cell apoptosis in normal mice and transgenic mice overexpressing rat androgen-binding protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Shbg (e-PCR), detects polymorphism
- UniSTS:144399

UniSTS:498767 (e-PCR)
- UniSTS:498767

Shbg (e-PCR), detects polymorphism
- UniSTS:498767

NoName (e-PCR)
- UniSTS:491362

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in primary spermatocyte growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sex hormone-binding globulin

Names: SBP; sex steroid-binding protein; testis-specific androgen-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011367.2 → NP_035497.1 sex hormone-binding globulin precursor

See identical proteins and their annotated locations for NP_035497.1

Status: VALIDATED

Source sequence(s)

AK010959, AL731687, BC120785

Consensus CDS

CCDS24899.1

UniProtKB/Swiss-Prot

P97497, Q0VB52

UniProtKB/TrEMBL

A0A158SIS9

Related

ENSMUSP00000005334.3, ENSMUST00000005334.3

Conserved Domains (2) summary

pfam00054
Location:76 → 206

Laminin_G_1; Laminin G domain

cl22861
Location:225 → 369

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69501108..69508852 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248838.3 → XP_011247140.1 sex hormone-binding globulin isoform X2

Conserved Domains (1) summary

cl22861
Location:76 → 152

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_011248837.3 → XP_011247139.1 sex hormone-binding globulin isoform X1

See identical proteins and their annotated locations for XP_011247139.1

UniProtKB/Swiss-Prot

P97497, Q0VB52

UniProtKB/TrEMBL

A0A158SIS9

Conserved Domains (2) summary

pfam00054
Location:76 → 206

Laminin_G_1; Laminin G domain

cl22861
Location:225 → 369

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...