Sgpl1 sphingosine phosphate lyase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgpl1provided by MGI
Official Full Name: sphingosine phosphate lyase 1provided by MGI
Primary source: MGI:MGI:1261415
See related: Ensembl:ENSMUSG00000020097 AllianceGenome:MGI:1261415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spl; S1PL; D10Xrf456
Summary: Predicted to enable sphinganine-1-phosphate aldolase activity. Acts upstream of or within several processes, including animal organ development; cellular hormone metabolic process; and face morphogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 37.5), large intestine adult (RPKM 19.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.14 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (60934421..60983463, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (61098642..61147684, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis.
Title: Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis.
Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.
Title: Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.
SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
Title: SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.
Title: Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.
Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development.
Title: Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development.
S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
Title: S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation.
Title: Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation.
Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy.
Title: Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy.
Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P2 receptor axis.
Title: Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P(2) receptor axis.
S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity.
Title: S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (7) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF036894 (e-PCR)
- UniSTS:185831

AI428538 (e-PCR)
- UniSTS:159984

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables sphinganine-1-phosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphinganine-1-phosphate aldolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Leydig cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within androgen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within estrogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within luteinization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitrogen compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sphingosine-1-phosphate lyase 1

Names: SP-lyase 1; SPL 1; sphingosine-1-phosphate aldolase

NP_001303602.1

EC 4.1.2.27

NP_001303603.1

EC 4.1.2.27

NP_033189.2

EC 4.1.2.27

XP_017169349.1

EC 4.1.2.27

XP_036011604.1

EC 4.1.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316673.1 → NP_001303602.1 sphingosine-1-phosphate lyase 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC123530, AI428538, AK049342, BB854743

Consensus CDS

CCDS35914.1

UniProtKB/Swiss-Prot

O54955, Q8C942, Q8R0X7

UniProtKB/TrEMBL

Q3UDJ2, Q4FK38

Related

ENSMUSP00000090155.6, ENSMUST00000092498.12

Conserved Domains (1) summary

cd06450
Location:146 → 507

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
NM_001316674.1 → NP_001303603.1 sphingosine-1-phosphate lyase 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC123530, AI428538, AK036747, BB854743, CD554088

Consensus CDS

CCDS35914.1

UniProtKB/Swiss-Prot

O54955, Q8C942, Q8R0X7

UniProtKB/TrEMBL

Q3UDJ2, Q4FK38

Conserved Domains (1) summary

cd06450
Location:146 → 507

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
NM_009163.4 → NP_033189.2 sphingosine-1-phosphate lyase 1

See identical proteins and their annotated locations for NP_033189.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC123530, AI428538, AK036747, BB620054, BB854743

Consensus CDS

CCDS35914.1

UniProtKB/Swiss-Prot

O54955, Q8C942, Q8R0X7

UniProtKB/TrEMBL

Q3UDJ2, Q4FK38

Related

ENSMUSP00000112975.2, ENSMUST00000122259.8

Conserved Domains (1) summary

cd06450
Location:146 → 507

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

60934421..60983463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155711.1 → XP_036011604.1 sphingosine-1-phosphate lyase 1 isoform X1

UniProtKB/Swiss-Prot

O54955, Q8C942, Q8R0X7

UniProtKB/TrEMBL

Q3UDJ2, Q4FK38

Conserved Domains (1) summary

cd06450
Location:146 → 507

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_017313860.3 → XP_017169349.1 sphingosine-1-phosphate lyase 1 isoform X1

UniProtKB/Swiss-Prot

O54955, Q8C942, Q8R0X7

UniProtKB/TrEMBL

Q3UDJ2, Q4FK38

Conserved Domains (1) summary

cd06450
Location:146 → 507

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...