Sftpc surfactant associated protein C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sftpcprovided by MGI
Official Full Name: surfactant associated protein Cprovided by MGI
Primary source: MGI:MGI:109517
See related: Ensembl:ENSMUSG00000022097 AllianceGenome:MGI:109517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SP5; SPC; SP-C; Sftp2; Bricd6; Sftp-2; pro-SpC
Summary: Predicted to enable identical protein binding activity. Located in cytoplasm and extracellular region. Is expressed in several structures, including lung and main bronchus epithelium. Used to study desquamative interstitial pneumonia. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward lung adult (RPKM 8709.5) See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.32 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70758381..70761521, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70520941..70524081, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain.
Title: Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain.
Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features.
Title: Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features.
Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
Title: Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice.
Title: Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice.
Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease.
Title: Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease.
Role of CCR2(+) Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium.
Title: Role of CCR2(+) Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium.
An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
Title: An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
CRISPR Sftpc gene editing successfully treats lethal monogenic lung disease in utero in a mouse model.
Title: CRISPR Gene Editing Successfully Treats Lethal Monogenic Lung Disease in Utero.
Yap and Taz (Wwtr1) have roles in surfactant protein C-expressing (SPC-expressing) alveolar epithelial type II cells during alveolar epithelial regeneration and resolution of lung inflammation in response to bacterial pneumonia-induced lung injury
Title: Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.
Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice.
Title: Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (15) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548424

NoName (e-PCR)
- UniSTS:548425

Sftpc (e-PCR), detects polymorphism
- UniSTS:516441

Sftpc (e-PCR), detects polymorphism
- UniSTS:516722

Sftpc (e-PCR), detects polymorphism
- UniSTS:496763

D14Mit33 (e-PCR), detects polymorphism
- UniSTS:127391

D14Mit32 (e-PCR), detects polymorphism
- UniSTS:116423

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in alveolar lamellar body	IBA Inferred from Biological aspect of Ancestor more info
located_in alveolar lamellar body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pulmonary surfactant-associated protein C

Names: pulmonary surfactant-associated proteolipid SPL(Val)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011359.2 → NP_035489.2 pulmonary surfactant-associated protein C

See identical proteins and their annotated locations for NP_035489.2

Status: VALIDATED

Source sequence(s)

AC122268, BY773034, CJ093163, CJ237354

Consensus CDS

CCDS27254.1

UniProtKB/Swiss-Prot

P21841

UniProtKB/TrEMBL

Q6P8P8

Related

ENSMUSP00000022692.4, ENSMUST00000022692.5

Conserved Domains (3) summary

smart00019
Location:1 → 193

SF_P; Pulmonary surfactant proteins

smart01039
Location:94 → 193

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

pfam08999
Location:1 → 93

SP_C-Propep; Surfactant protein C, N terminal propeptide