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    Frrs1 ferric-chelate reductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20321, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Frrs1provided by MGI
    Official Full Name
    ferric-chelate reductase 1provided by MGI
    Primary source
    MGI:MGI:108076
    See related
    Ensembl:ENSMUSG00000033386 AllianceGenome:MGI:108076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SDR-2; Sdfr2
    Summary
    Enables oxidoreductase activity, acting on metal ions. Involved in cellular iron ion homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in liver left lobe; liver lobe; and liver right lobe. Orthologous to human FRRS1 (ferric chelate reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E18 (RPKM 6.5), liver E14 (RPKM 6.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 G1; 3 50.49 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116653212..116701363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116859567..116907714)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4582 Neighboring gene predicted gene, 40128 Neighboring gene predicted gene, 29736 Neighboring gene STARR-seq mESC enhancer starr_08799 Neighboring gene palmdelphin Neighboring gene STARR-seq mESC enhancer starr_08800 Neighboring gene predicted gene, 32148 Neighboring gene predicted gene, 52613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body. Zhu Y, et al. Insect Biochem Mol Biol, 2003 May. PMID 12706633
    2. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Vargas JD, et al. Biochim Biophys Acta, 2003 Sep 23. PMID 14499595
    3. Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Shirozu M, et al. Genomics, 1996 Nov 1. PMID 8938438
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on metal ions IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on metal ions IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ferric-chelate reductase 1
    Names
    stromal cell derived factor receptor 2
    stromal cell-derived receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113478.2 → NP_001106950.1  ferric-chelate reductase 1 precursor

      See identical proteins and their annotated locations for NP_001106950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC170869, AC174779
      Consensus CDS
      CCDS17792.1
      UniProtKB/Swiss-Prot
      P97301, Q3TJV0, Q3UMF5, Q8K385
      UniProtKB/TrEMBL
      A0A0G2JFP4
      Related
      ENSMUSP00000039487.7, ENSMUST00000040260.11
      Conserved Domains (3) summary
      cd08760
      Location:320 → 533
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:192 → 354
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:32 → 155
      Reeler; Reeler domain

    2. NM_009146.4 → NP_033172.2  ferric-chelate reductase 1 precursor

      See identical proteins and their annotated locations for NP_033172.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC170869
      Consensus CDS
      CCDS17792.1
      UniProtKB/Swiss-Prot
      P97301, Q3TJV0, Q3UMF5, Q8K385
      UniProtKB/TrEMBL
      A0A0G2JFP4
      Related
      ENSMUSP00000143255.2, ENSMUST00000195905.5
      Conserved Domains (3) summary
      cd08760
      Location:320 → 533
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:192 → 354
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:32 → 155
      Reeler; Reeler domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      116653212..116701363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319511.2 → XP_017175000.1  ferric-chelate reductase 1 isoform X1

      UniProtKB/Swiss-Prot
      P97301, Q3TJV0, Q3UMF5, Q8K385
      Conserved Domains (3) summary
      cd08760
      Location:287 → 500
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:192 → 321
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:32 → 155
      Reeler; Reeler domain

    2. XM_006501185.5 → XP_006501248.1  ferric-chelate reductase 1 isoform X2

      Conserved Domains (2) summary
      cd08760
      Location:38 → 251
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cl14783
      Location:1 → 72
      DOMON_like; Domon-like ligand-binding domains

    RNA

    1. XR_001783669.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K385.1 GenPept UniProtKB/Swiss-Prot:Q8K385

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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