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    Sdf2 stromal cell derived factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 20316, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sdf2provided by MGI
    Official Full Name
    stromal cell derived factor 2provided by MGI
    Primary source
    MGI:MGI:108019
    See related
    Ensembl:ENSMUSG00000002064 AllianceGenome:MGI:108019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable misfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in endoplasmic reticulum. Predicted to be part of chaperone complex. Orthologous to human SDF2 (stromal cell derived factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 68.0), genital fat pad adult (RPKM 59.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sdf2 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78136817..78146310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78245746..78255496)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein interacting with cyclin A1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78029402-78029555 Neighboring gene SPT6, histone chaperone and transcription elongation factor Neighboring gene STARR-seq mESC enhancer starr_30092 Neighboring gene small nuclear ribonucleoprotein N pseudogene Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene predicted gene 3948 Neighboring gene ribosomal protein S6 kinase related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Stromal cell derived factor-2 (Sdf2): a novel protein expressed in mouse. Lorenzon-Ojea AR, et al. Int J Biochem Cell Biol, 2014 Aug. PMID 24878610
    2. Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. Hamada T, et al. Gene, 1996 Oct 17. PMID 8918255
    3. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Carramolino L, et al. Gene, 1997 Aug 22. PMID 9305759
    4. Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Shirozu M, et al. Genomics, 1996 Nov 1. PMID 8938438
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107120

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stromal cell-derived factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359106.2 → NP_001346035.2  stromal cell-derived factor 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591070

    2. NM_001404338.1 → NP_001391267.1  stromal cell-derived factor 2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591070

    3. NM_001404339.1 → NP_001391268.1  stromal cell-derived factor 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591070

    4. NM_001404340.1 → NP_001391269.1  stromal cell-derived factor 2 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591070

    5. NM_001404341.1 → NP_001391270.1  stromal cell-derived factor 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591070

    6. NM_001404342.1 → NP_001391271.1  stromal cell-derived factor 2 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591070

    7. NM_001404343.1 → NP_001391272.1  stromal cell-derived factor 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL591070
      Related
      ENSMUST00000154080.2

    8. NM_001404344.1 → NP_001391273.1  stromal cell-derived factor 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL591070

    9. NM_009143.4 → NP_033169.4  stromal cell-derived factor 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591070
      Consensus CDS
      CCDS25096.2
      UniProtKB/Swiss-Prot
      P97307, Q9DCT5
      UniProtKB/TrEMBL
      Q6P5I1
      Related
      ENSMUSP00000002133.10, ENSMUST00000002133.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78136817..78146310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCT5.1 GenPept UniProtKB/Swiss-Prot:Q9DCT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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