Scg3 secretogranin III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scg3provided by MGI
Official Full Name: secretogranin IIIprovided by MGI
Primary source: MGI:MGI:103032
See related: Ensembl:ENSMUSG00000032181 AllianceGenome:MGI:103032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chgd; SgIII; 1B1075
Summary: Acts upstream of or within protein localization to secretory granule. Located in secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human SCG3 (secretogranin III). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 14.7), cortex adult (RPKM 13.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 42.32 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (75550648..75591733, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (75643366..75685959, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative ligandomics implicates secretogranin III as a disease-restricted angiogenic factor in laser-induced choroidal neovascularization.
Title: Comparative ligandomics implicates secretogranin III as a disease-restricted angiogenic factor in laser-induced choroidal neovascularization.
Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson's disease.
Title: Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson's disease.
Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy.
Title: Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy.
Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization.
Title: Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization.
Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.
Title: Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.
This review summarizes our current knowledge of Scg3 as a regulatory protein of secretory granules, highlights its new role as a highly disease-selective angiogenic factor, and envisions Scg3 inhibitors as "selective angiogenesis blockers" for targeted therapy of diabetic retinopathy.[ review]
Title: Secretogranin III: a diabetic retinopathy-selective angiogenic factor.
we show by RNA silencing that CPE and SgIII play a synergistic role in the trafficking of POMC to granules of the regulated secretory pathway in AtT20 cells
Title: Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells.
SgIII knockdown impairs intracellular retention of chromogranin A and proopiomelanocortin in AtT-20 cells.
Title: Multiple sorting systems for secretory granules ensure the regulated secretion of peptide hormones.
The robust expression of SgIII in astrocytes and its regulation in the injured brain suggest both intracellular and extracellular roles for this glial granin in the physiology and repair/damage of neuronal circuits.
Title: Secretogranin III is an astrocyte granin that is overexpressed in reactive glia.
SCG2, as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules.
Title: Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI385542 (e-PCR)
- UniSTS:179937

Scg3 (e-PCR), detects polymorphism
- UniSTS:144373

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein localization to secretory granule	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to secretory granule	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: secretogranin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164790.1 → NP_001158262.1 secretogranin-3 isoform 2 precursor

See identical proteins and their annotated locations for NP_001158262.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to variant 1.

Source sequence(s)

AK139140, AK164089, BU058741

Consensus CDS

CCDS90627.1

UniProtKB/Swiss-Prot

P47867

Related

ENSMUSP00000149561.2, ENSMUST00000213324.2

Conserved Domains (1) summary

pfam15467
Location:20 → 466

SGIII; Secretogranin-3
NM_009130.3 → NP_033156.1 secretogranin-3 isoform 1 precursor

See identical proteins and their annotated locations for NP_033156.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK139140, BU058741

Consensus CDS

CCDS23347.1

UniProtKB/Swiss-Prot

P47867, Q3UTT1, Q3UZT8, Q8R1D7

Related

ENSMUSP00000034699.7, ENSMUST00000034699.8

Conserved Domains (1) summary

pfam15467
Location:20 → 471

SGIII; Secretogranin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

75550648..75591733 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313220.3 → XP_017168709.1 secretogranin-3 isoform X2

Conserved Domains (1) summary

pfam15467
Location:29 → 433

SGIII; Secretogranin-3
XM_006510881.5 → XP_006510944.1 secretogranin-3 isoform X1

Conserved Domains (1) summary

pfam15467
Location:29 → 438

SGIII; Secretogranin-3